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  • 1
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    Osteosarcopenia predicts poor survival in patients with cirrhosis: a retrospective study
    Springer Science and Business Media LLC ; 2023
    In:  BMC Gastroenterology Vol. 23, No. 1 ( 2023-06-05)
    Details
    In: BMC Gastroenterology, Springer Science and Business Media LLC, Vol. 23, No. 1 ( 2023-06-05)
    Abstract: Osteosarcopenia, defined as the coexistence of sarcopenia and osteoporosis, is associated with adverse clinical outcomes. The present study investigated the prognostic significance of osteosarcopenia in patients with cirrhosis. Methods This retrospective study evaluated 126 patients with cirrhosis. Participants were classified into three groups based on the presence or absence of (1) sarcopenia and/or osteoporosis; and (2) Child–Pugh (CP) class B/C cirrhosis and/or osteosarcopenia, and the cumulative survival rates were compared between the groups. Cox proportional hazards model was used to identify independent factors associated with mortality. Sarcopenia and osteoporosis were diagnosed according to the Japan Society of Hepatology and the World Health Organization criteria, respectively. Results Among the 126 patients, 24 (19.0%) had osteosarcopenia. Multivariate analysis identified osteosarcopenia as a significant and independent prognostic factor. The cumulative survival rates were significantly lower in patients with osteosarcopenia than in those without (1/3/5-year survival rates = 95.8%/73.7%/68.0% vs. 100%/93.6%/86.5%, respectively; p  = 0.020). Patients with osteosarcopenia, but not sarcopenia or osteoporosis alone, had significantly lower cumulative survival rates than those without both conditions ( p  = 0.019). Furthermore, patients with both CP class B/C and osteosarcopenia had significantly lower cumulative survival rates than those without both ( p   〈  0.001) and with either condition ( p   〈  0.001). Conclusions Osteosarcopenia was significantly associated with mortality in patients with cirrhosis. The cumulative survival rates were lower in patients with osteosarcopenia than in those without both conditions. Additionally, comorbid osteosarcopenia worsened the prognosis of patients with CP class B/C. Therefore, simultaneous evaluation of both sarcopenia and osteoporosis is crucial to better predict the prognosis.
    Type of Medium: Online Resource
    ISSN: 1471-230X
    URL: Article
    DOI: 10.1186/s12876-023-02835-y
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2041351-8
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  • 2
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    Serum Insulin-Like Growth Factor 1 Levels, Facture Risk Assessment Tool Scores and Bone Disorders in Patients with Primary Biliary Cholangitis
    MDPI AG ; 2022
    In:  Diagnostics Vol. 12, No. 8 ( 2022-08-12), p. 1957-
    Details
    In: Diagnostics, MDPI AG, Vol. 12, No. 8 ( 2022-08-12), p. 1957-
    Abstract: Insulin-like growth factor 1 (IGF-1) plays an important role in bone growth and maintenance, and its decreased levels are associated with bone disorders. This study aimed to evaluate the association of serum IGF-1 levels with osteoporosis, prevalent fractures and fracture risk based on the Fracture Risk Assessment Tool (FRAX) in patients with primary biliary cholangitis (PBC). This study included 127 consecutive patients with PBC. Based on the baseline serum IGF-1 levels, the participants were classified into the low (L)-, intermediate (I)- and high (H)-IGF-1 groups. According to the FRAX score, high fracture risk was defined as a 10-year major osteoporotic fracture probability (FRAX-MOF) ≥ 20% or a 10-year hip fracture probability (FRAX-HF) ≥ 3%. The serum IGF-1 levels were positively correlated with bone mineral density, and were negatively correlated with the FRAX-MOF/FRAX-HF. The L-IGF-1 group had the highest prevalence of osteoporosis (58.1%), prevalent fracture (48.4%) and high fracture risk (71.0%). Meanwhile, the H-IGF-1 group had the lowest prevalence of osteoporosis (9.7%), prevalent fracture (12.9%) and high fracture risk (9.7%). The prevalence of these events increased stepwise with decreasing serum IGF-1 levels. The cutoff values of IGF-1 for predicting osteoporosis, prevalent fracture and high fracture risk were 61.5 ng/mL (sensitivity/specificity, 0.545/0.894), 69.5 ng/mL (0.633/0.784) and 61.5 ng/mL (0.512/0.929), respectively. Serum IGF-1 levels were associated with bone disorders and the FRAX-derived fracture risk, and may be a useful indicator for initiating therapeutic intervention to prevent the incidence of fracture in patients with PBC.
    Type of Medium: Online Resource
    ISSN: 2075-4418
    URL: Article
    DOI: 10.3390/diagnostics12081957
    Language: English
    Publisher: MDPI AG
    Publication Date: 2022
    detail.hit.zdb_id: 2662336-5
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  • 3
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    Real-time breath ammonia measurement using a novel cuprous bromide sensor device in patients with chronic liver disease: a feasibility and pilot study
    IOP Publishing ; 2021
    In:  Journal of Breath Research Vol. 15, No. 2 ( 2021-04-01), p. 026010-
    Details
    In: Journal of Breath Research, IOP Publishing, Vol. 15, No. 2 ( 2021-04-01), p. 026010-
    Abstract: We developed a small portable sensor device using a p-type semiconductor cuprous bromide (CuBr) thin film to measure breath ammonia in real time with highsensitivity and selectivity. Breath ammonia is reportedly associated with chronic liver disease (CLD). We aimed to assess the practical utility of the novel CuBr sensor device for exhaled breath ammonia and the correlation between breath and blood ammonia in CLD patients. This was a feasibility and pilot clinical study of 21 CLD patients and 18 healthy volunteers. Breath ammonia was directly and quickly measured using the novel CuBr sensor device and compared with blood ammonia measured at the same time. CLD patients had significantly higher breath ammonia levels than healthy subjects ( p = 1.51 × 10 −3 ), with the level of significance being similar to that for blood ammonia levels ( p = 0.024). Significant differences were found in breath and blood ammonia between the healthy and cirrhosis groups ( p = 2.97 × 10 −3 and 3.76 × 10 −3 , respectively). Significant, positive correlations between breath and blood ammonia were noted in the CLD group ( R = 0.747, p = 1.00 × 10 −4 ), healthy/CLD group ( R = 0.741, p = 6.75 × 10 −8 ), and cirrhosis group ( R = 0.744, p = 9.52 × 10 −4 ). In conclusion, the newly developed, easy-to-use, and small portable CuBr sensor device was able to non-invasively measure breath ammonia in real time. Breath ammonia measured using the device was correlated with blood ammonia and the presence of liver cirrhosis, and might be an alternative surrogate biomarker to blood ammonia.
    Type of Medium: Online Resource
    ISSN: 1752-7155 , 1752-7163
    URL: Article
    DOI: 10.1088/1752-7163/abb477
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2021
    detail.hit.zdb_id: 2381007-5
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  • 4
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    Image_8.tif
    Frontiers Media SA ; 2023
    In:  Frontiers in Nutrition Vol. 10 ( 2023-9-20)
    Details
    In: Frontiers in Nutrition, Frontiers Media SA, Vol. 10 ( 2023-9-20)
    Abstract: Malnutrition, which increases the risk of liver disease-related events and mortality, is a serious complication in cirrhosis. This study aimed to investigate whether the geriatric nutritional risk index (GNRI) could predict the long-term prognosis in patients with cirrhosis. Methods We retrospectively evaluated 266 patients with cirrhosis and classified them into two groups based on baseline GNRI scores: risk (≤98, n  = 104) and no-risk groups ( & gt;98, n  = 162). The cumulative survival rates were compared between the two groups in patients with compensated and decompensated cirrhosis, respectively. Cox proportional hazards regression analysis was used to identify significant and independent factors associated with mortality. Results The median observation period was 54.9 (33.6–61.7) months and 65 (24.4%) liver disease-related deaths occurred during the follow-up period. The GNRI scores significantly and inversely correlated with Child-Pugh score ( r  = −0.579), model for end-stage liver disease score ( r  = −0.286), and Mac-2 binding protein glycosylation isomer ( r  = −0.494). Multivariate analysis identified low GNRI as a significant and independent factor associated with mortality [overall cohort: hazard ratio (HR), 0.926; p   & lt; 0.001; compensated cirrhosis: HR, 0.947; p  = 0.003; decompensated cirrhosis: HR, 0.923; p   & lt; 0.001]. The risk group demonstrated significantly lower cumulative survival rates than the no-risk group in overall cohort, and patients with compensated and decompensated cirrhosis ( p   & lt; 0.001, & lt;0.001, and = 0.013, respectively). Conclusion Low GNRI was associated with poor long-term prognosis in both patients with compensated and decompensated cirrhosis. Therefore, the GNRI is a simple and useful tool for predicting prognosis and modifying the nutritional status in patients with cirrhosis.
    Type of Medium: Online Resource
    ISSN: 2296-861X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
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    URL: Article
    DOI: 10.3389/fnut.2023.1269399
    DOI: 10.3389/fnut.2023.1269399.s001
    DOI: 10.3389/fnut.2023.1269399.s002
    DOI: 10.3389/fnut.2023.1269399.s003
    DOI: 10.3389/fnut.2023.1269399.s004
    DOI: 10.3389/fnut.2023.1269399.s005
    DOI: 10.3389/fnut.2023.1269399.s006
    DOI: 10.3389/fnut.2023.1269399.s007
    DOI: 10.3389/fnut.2023.1269399.s008
    DOI: 10.3389/fnut.2023.1269399.s009
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2776676-7
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  • 5
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    Table_1.DOCX
    Frontiers Media SA ; 2023
    In:  Frontiers in Medicine Vol. 10 ( 2023-7-24)
    Details
    In: Frontiers in Medicine, Frontiers Media SA, Vol. 10 ( 2023-7-24)
    Abstract: Insulin-like growth factor 1 (IGF-1), which is primarily produced in hepatocytes and is associated with liver functional reserve, plays a crucial role in the pathological condition of cirrhosis. This study aimed to investigate the usefulness of serum IGF-1 levels for predicting the long-term prognosis and decompensation development in patients with cirrhosis. Methods We retrospectively evaluated 148 patients with cirrhosis and divided them into three groups according to baseline IGF-1 levels: low (L)-, intermediate (I)-, and high (H)-IGF-1 groups. The cumulative survival rates were compared among these groups in compensated and decompensated cirrhosis, respectively. Significant and independent factors associated with mortality and decompensation development were identified using Cox proportional hazards regression analysis. Results The median observation period was 57.1 (41.7–63.2) months. Thirty (20.3%) patients died of liver disease-related events and 21 (22.3%) patients with compensated cirrhosis developed decompensation. Multivariate analysis identified low serum IGF-1 levels as a significant and independent factor associated with mortality (all patients: hazard ratio [HR], 0.967; p  = 0.004; patients with compensated cirrhosis: HR, 0.927; p  = 0.002). The cumulative survival rates were significantly lower in the L-IGF-1 group than in the H-IGF-1 and I-IGF-1 groups (all patients: p   & lt; 0.001 and = 0.009; patients with compensated cirrhosis: p  = 0.012 and 0.003, respectively). However, in decompensated cirrhosis, the cumulative survival rates demonstrated no significant differences among the three groups. The cumulative decompensation incidence rates were significantly higher in the L-IGF-1 group than in the H-IGF-1 and I-IGF-1 groups ( p   & lt; 0.001 and = 0.009, respectively). Low serum IGF-1 levels were significantly and independently associated with decompensation development (HR, 0.939; p   & lt; 0.001). Conclusion Low serum IGF-1 levels were significantly and independently associated with decompensation development and poor long-term prognosis in patients with compensated cirrhosis. Therefore, IGF-1 may be useful for predicting decompensation-related events and should be regularly monitored in the management of compensated phase.
    Type of Medium: Online Resource
    ISSN: 2296-858X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmed.2023.1233928
    DOI: 10.3389/fmed.2023.1233928.s001
    DOI: 10.3389/fmed.2023.1233928.s002
    DOI: 10.3389/fmed.2023.1233928.s003
    DOI: 10.3389/fmed.2023.1233928.s004
    DOI: 10.3389/fmed.2023.1233928.s005
    DOI: 10.3389/fmed.2023.1233928.s006
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2775999-4
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  • 6
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    Prognostic significance of sarcopenia and severe vitamin D deficiency in patients with cirrhosis
    Wiley ; 2023
    In:  JGH Open Vol. 7, No. 5 ( 2023-05), p. 351-357
    Details
    In: JGH Open, Wiley, Vol. 7, No. 5 ( 2023-05), p. 351-357
    Abstract: Sarcopenia and severe vitamin D deficiency are associated with malnutrition and poor prognosis. We investigated the impact of the comorbidity of Child–Pugh (CP) class B/C cirrhosis and the aforementioned complications on the prognosis of patients with cirrhosis. Methods We retrospectively evaluated 104 patients with cirrhosis. The cumulative survival rates were compared between patients with and without both or either of these disease conditions: CP class B/C and complications (sarcopenia or severe vitamin D deficiency). Sarcopenia was diagnosed according to the Japan Society of Hepatology criteria. Severe vitamin D deficiency was defined as levels of 25‐hydroxyvitamin D 〈 10 ng/mL in serum. Results The prevalence of CP class B/C, sarcopenia, and severe vitamin D deficiency was 26.9%, 38.5%, and 24.0%, respectively. Patients with both CP class B/C and sarcopenia had significantly lower survival rates than those without both (hazard ratio [HR] = 6.101; P   〈  0.001) and with either condition (HR = 6.137; P  = 0.001). Similarly, patients with both CP class B/C and severe vitamin D deficiency or with either condition had significantly lower survival rates than those without both conditions (HR = 8.135 or 3.189; P   〈  0.001 or =0.025, respectively). CP class B/C (HR = 3.354; P  = 0.006) and severe vitamin D deficiency (HR = 2.445; P  = 0.044) were independent prognostic factors. Conclusions The coexistence of CP class B/C and sarcopenia or severe vitamin D deficiency worsened the prognosis of patients with cirrhosis. Nutritional assessments such as sarcopenia and vitamin D status should be considered to better evaluate disease conditions and patient prognosis.
    Type of Medium: Online Resource
    ISSN: 2397-9070 , 2397-9070
    URL: Issue
    URL: Article
    DOI: 10.1002/jgh3.v7.5
    DOI: 10.1002/jgh3.12900
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2919809-4
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  • 7
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    The Geriatric Nutritional Risk Index predicts sarcopenia in patients with cirrhosis
    Springer Science and Business Media LLC ; 2023
    In:  Scientific Reports Vol. 13, No. 1 ( 2023-03-08)
    Details
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-03-08)
    Abstract: Patients with cirrhosis are at high risk for sarcopenia and malnutrition, which are associated with reduced quality of life and increased mortality. We investigated the relationship between the Geriatric Nutritional Risk Index (GNRI) and sarcopenia/gait speed and assessed the usefulness of the GNRI for predicting sarcopenia in patients with cirrhosis. We evaluated 202 patients with cirrhosis and divided them into three groups based on baseline GNRI values: low (L)-GNRI ( 〈  94.0, n = 49), intermediate (I)-GNRI (between 94.0 and 109.5, n = 103), and high (H)-GNRI groups ( 〉  109.5, n = 50). Sarcopenia was diagnosed according to the criteria of the Japan Society of Hepatology. The prevalence of sarcopenia and slow gait speed was the lowest in the H-GNRI group (8.0% and 26.0%, respectively) and the highest in the L-GNRI group (49.0% and 44.9%, respectively). They increased stepwise with a decline in the GNRI group ( p   〈  0.001 and p  = 0.05, respectively). The GNRI values were significantly and positively correlated with handgrip strength, skeletal muscle mass index, and gait speed. Multivariate analysis identified lower GNRI as an independent risk factor for sarcopenia. The optimal cutoff value of the GNRI for predicting sarcopenia was 102.1 (sensitivity/specificity, 0.768/0.630). The GNRI was significantly associated with sarcopenia and physical performance and could be a helpful screening tool for predicting sarcopenia in patients with cirrhosis.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    URL: Article
    DOI: 10.1038/s41598-023-31065-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2615211-3
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  • 8
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    Safety and efficacy of pentazocine–midazolam combination for pain and anxiety relief in radiofrequency ablation therapy for hepatocellular carcinoma
    Wiley ; 2022
    In:  JGH Open Vol. 6, No. 8 ( 2022-08), p. 569-576
    Details
    In: JGH Open, Wiley, Vol. 6, No. 8 ( 2022-08), p. 569-576
    Abstract: Radiofrequency ablation (RFA) therapy is frequently used as first‐line treatment for small hepatocellular carcinoma (HCC). RFA is often associated with pain; however, no definitive solution has been established for its relief. We retrospectively analyzed the safety and efficacy of the combination of pentazocine and midazolam to relieve pain experienced by HCC patients undergoing RFA. Methods We studied 77 patients with 98 HCCs treated with RFA between January 2015 and August 2019. Patients were divided into two groups: the sedative‐free group, which included those who received pentazocine alone, and the pentazocine–midazolam group, which included those who received a combination of pentazocine and midazolam. The degrees of analgesia and sedation were evaluated using the numerical rating scale (NRS) and the Richmond Agitation‐Sedation Scale (RASS), respectively. Other parameters such as treatment time, awakening time, midazolam dosage, vital signs, local recurrence rate, and time to recurrence were also examined. Results The median NRS score and RASS score were significantly lower in the pentazocine–midazolam group. Ninety‐five percent of patients in the pentazocine–midazolam group had no memory of the RFA session. The treatment time and awakening time were prolonged for the pentazocine–midazolam group. No significant differences in oxygen saturation, recurrence rates, and time to local recurrence were observed between groups. Conclusion A combination of pentazocine and midazolam is safe and effective for pain and anxiety relief experienced by patients undergoing RFA for local treatment of HCC.
    Type of Medium: Online Resource
    ISSN: 2397-9070 , 2397-9070
    URL: Issue
    URL: Article
    DOI: 10.1002/jgh3.v6.8
    DOI: 10.1002/jgh3.12788
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2919809-4
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  • 9
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    Protein kinase C delta enhances the diagnostic performance of hepatocellular carcinoma
    Informa UK Limited ; 2024
    In:  Biomarkers Vol. 29, No. 2 ( 2024-02-17), p. 55-67
    Details
    In: Biomarkers, Informa UK Limited, Vol. 29, No. 2 ( 2024-02-17), p. 55-67
    Type of Medium: Online Resource
    ISSN: 1354-750X , 1366-5804
    URL: Article
    DOI: 10.1080/1354750X.2024.2312990
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2024
    detail.hit.zdb_id: 1496523-9
    SSG: 12
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  • 10
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    Protein Kinase C Delta Is a Novel Biomarker for Hepatocellular Carcinoma
    Elsevier BV ; 2023
    In:  Gastro Hep Advances Vol. 2, No. 1 ( 2023), p. 83-95
    Details
    In: Gastro Hep Advances, Elsevier BV, Vol. 2, No. 1 ( 2023), p. 83-95
    Type of Medium: Online Resource
    ISSN: 2772-5723
    URL: Article
    DOI: 10.1016/j.gastha.2022.07.020
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 3113057-4
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