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  • 1
    In: Circulation: Cardiovascular Genetics, Ovid Technologies (Wolters Kluwer Health), Vol. 8, No. 5 ( 2015-10), p. 653-664
    Abstract: Mutations in thin-filament proteins have been linked to hypertrophic cardiomyopathy, but it has never been demonstrated that variants identified in the TNNC1 (gene encoding troponin C) can evoke cardiac remodeling in vivo. The goal of this study was to determine whether TNNC1 can be categorized as an hypertrophic cardiomyopathy susceptibility gene, such that a mouse model can recapitulate the clinical presentation of the proband. Methods and Results— The TNNC1-A8V proband diagnosed with severe obstructive hypertrophic cardiomyopathy at 34 years of age exhibited mild-to-moderate thickening in left and right ventricular walls, decreased left ventricular dimensions, left atrial enlargement, and hyperdynamic left ventricular systolic function. Genetically engineered knock-in (KI) mice containing the A8V mutation (heterozygote=KI-TnC-A8V +/− ; homozygote=KI-TnC-A8V +/+ ) were characterized by echocardiography and pressure–volume studies. Three-month-old KI-TnC-A8V +/+ mice displayed decreased ventricular dimensions, mild diastolic dysfunction, and enhanced systolic function, whereas KI-TnC-A8V +/− mice displayed cardiac restriction at 14 months of age. KI hearts exhibited atrial enlargement, papillary muscle hypertrophy, and fibrosis. Liquid chromatography–mass spectroscopy was used to determine incorporation of mutant cardiac troponin C (≈21%) into the KI-TnC-A8V +/− cardiac myofilament. Reduced diastolic sarcomeric length, increased shortening, and prolonged Ca 2+ and contractile transients were recorded in intact KI-TnC-A8V +/− and KI-TnC-A8V +/+ cardiomyocytes. Ca 2+ sensitivity of contraction in skinned fibers increased with mutant gene dose: KI-TnC-A8V +/+ 〉 KI-TnC-A8V +/− 〉 wild-type, whereas KI-TnC-A8V +/+ relaxed more slowly on flash photolysis of diazo-2. Conclusions— The TNNC1-A8V mutant increases the Ca 2+ -binding affinity of the thin filament and elicits changes in Ca 2+ homeostasis and cellular remodeling, which leads to diastolic dysfunction. These in vivo alterations further implicate the role of TNNC1 mutations in the development of cardiomyopathy.
    Type of Medium: Online Resource
    ISSN: 1942-325X , 1942-3268
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2015
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    detail.hit.zdb_id: 2457085-0
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  • 2
    Online Resource
    Online Resource
    Elsevier BV ; 2018
    In:  Complementary Therapies in Clinical Practice Vol. 30 ( 2018-02), p. 14-18
    In: Complementary Therapies in Clinical Practice, Elsevier BV, Vol. 30 ( 2018-02), p. 14-18
    Type of Medium: Online Resource
    ISSN: 1744-3881
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2018
    detail.hit.zdb_id: 2181895-2
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  • 3
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2019
    In:  CNS Spectrums Vol. 24, No. 1 ( 2019-02), p. 198-199
    In: CNS Spectrums, Cambridge University Press (CUP), Vol. 24, No. 1 ( 2019-02), p. 198-199
    Abstract: Psychological risk factors that lead to impaired work performance, negatively impacting mental and physical health, have emerged as a concern across clinical settings. Although depression and anxiety are linked to poor physician mental health, physician burnout characterized by work related stress due to chronic exhaustion from clinical work, cynicism toward meaning of the medical profession, and feelings of inadequacy toward work related accomplishments, may be an even stronger indicator of well-being. Literature suggests that work satisfaction among physicians is rapidly deteriorating owing to high rates of burn out and poor mental health. Although the relationship between work burnout (WB) and negative affectivity has been well documented, the association with positive affect, such as trait forgiveness (TF) has been overlooked. On that note, research shows that lifetime stress severity and lower levels of forgiveness predict worse mental and physical health. Since TF has been linked strongly with healthy workplace relationships, positive occupational outcomes and general well-being, its association with WB remains to be investigated. Therefore, the aim of the present study was to explore the link between TF and WB among physicians. We hypothesized that TF would be associated with reduced levels of burnout. Method A total of 62 (F=23) medical residents at a Teaching Hospital consented for the study. Residents were administered surveys on WB (Maslach BurnoutInventory), workplace bullying, personal bullying (PB), interpersonal rejection sensitivity (IRS), perceived stress scale (PSS), TF, anxiety, and depression, all of which were anonymously submitted via electronically. Hierarchical multiple regression (HMR) models were used to determine the associations between WB, work environment social factors and TF. A p-value of 〈 0.05 was considered significant. Results The mean age 33.1±SD 4.2 years. HMR analysis using WB as main outcome contained 6 predictors: Model 1 contained depression and anxiety, Model 2 added PB, Model 3 added IRS and PSS, Model 4 added TF. Anxiety and TF were the only significant predictors (p= 〉 0.05) accounting for 10.4% and 17.5% of the variance in WB scores, respectively. Conclusions The novel finding of the present study is that TF was associated with low levels of burnout. Additionally, WB was found to be linked to anxiety and depression which is in line with previous research. These data suggest that TF could be a potential resolution to the deleterious influence of burnout. Further exploration is needed in order to understand the psychology of forgiveness as a potential adjuvant and/or therapeutic intervention for physicians’ burnout. These results suggest that strategies including forgiveness training aimed at decreasing WB while increasing job satisfaction among physicians warrant further exploration. Funding Acknowledgements: no funding
    Type of Medium: Online Resource
    ISSN: 1092-8529 , 2165-6509
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2149753-9
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  • 4
    Online Resource
    Online Resource
    Hindawi Limited ; 2016
    In:  Case Reports in Medicine Vol. 2016 ( 2016), p. 1-6
    In: Case Reports in Medicine, Hindawi Limited, Vol. 2016 ( 2016), p. 1-6
    Abstract: Background . Recently, the importance of the gut microbiota in the pathogenesis of several disorders has gained clinical interests. Among exogenous factors affecting gut microbiome, diet appears to have the largest effect. Fatty acids, especially omega-3 polyunsaturated, ameliorate a range of several diseases, including cardiometabolic and inflammatory and cancer. Fatty acids associated beneficial effects may be mediated, to an important extent, through changes in gut microbiota composition. We sought to understand the changes of the gut microbiota in response to an omega-3 rich diet. Case Presentation. This case study investigated changes of gut microbiota with an omega-3 rich diet. Fecal samples were collected from a 45-year-old male who consumed 600 mg of omega-3 daily for 14 days. After the intervention, species diversity was decreased, but several butyrate-producing bacteria increased. There was an important decrease in Faecalibacterium prausnitzii and Akkermansia spp. Gut microbiota changes were reverted after the 14-day washout . Conclusion . Some of the health-related benefits of omega-3 may be due, in part, to increases in butyrate-producing bacteria. These findings may shed light on the mechanisms explaining the effects of omega-3 in several chronic diseases and may also serve as an existing foundation for tailoring personalized medical treatments.
    Type of Medium: Online Resource
    ISSN: 1687-9627 , 1687-9635
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2502642-2
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  • 5
    Online Resource
    Online Resource
    American Psychological Association (APA) ; 2015
    In:  Couple and Family Psychology: Research and Practice Vol. 4, No. 1 ( 2015-03), p. 39-48
    In: Couple and Family Psychology: Research and Practice, American Psychological Association (APA), Vol. 4, No. 1 ( 2015-03), p. 39-48
    Type of Medium: Online Resource
    ISSN: 2160-410X , 2160-4096
    Language: English
    Publisher: American Psychological Association (APA)
    Publication Date: 2015
    detail.hit.zdb_id: 2677133-0
    SSG: 5,2
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  • 6
    In: Pediatric Exercise Science, Human Kinetics, Vol. 30, No. 4 ( 2018-11-1), p. 480-486
    Abstract: Purpose : Childhood and adolescent obesity is a major international public health crisis. It is crucial to prevent the negative effects of obesity at an early age by implementing appropriate lifestyle interventions, such as exercise training. We evaluated the effects of a combined resistance and aerobic exercise training (CET) regimen on arterial stiffness, vasoactive substances, inflammatory markers, metabolic profile, and body composition in obese adolescent girls. Methods : A total of 30 obese adolescent girls were randomly assigned to a CET (n = 15) or a control group (n = 15). The CET group trained for 3 days per week. Plasma nitric oxide, endothelin-1, C-reactive protein, arterial stiffness, glucose, insulin, the adiponectin/leptin ratio, and body fat were measured before and after 12 weeks. Results : There were significant increases ( P   〈  .05) in nitric oxide (4.0 μM) and adiponectin/leptin ratio (0.33); and decreases ( P   〈  .05) in arterial stiffness (−1.0 m/s), C-reactive protein (−0.5 mg/L), glucose (−1.2 mmol/L), insulin (−17.1 μU/mL), and body fat (−3.6%) following CET compared with control. There were no significant changes in endothelin-1 after CET or control. Conclusions : The findings of this study indicate that CET improves arterial stiffness, nitric oxide, and inflammatory and metabolic markers in obese adolescent girls. CET may have important health implications for the prevention of atherosclerosis at an early age.
    Type of Medium: Online Resource
    ISSN: 0899-8493 , 1543-2920
    Language: Unknown
    Publisher: Human Kinetics
    Publication Date: 2018
    SSG: 31
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  • 7
    Online Resource
    Online Resource
    Elsevier BV ; 2016
    In:  Burnout Research Vol. 3, No. 3 ( 2016-09), p. 63-68
    In: Burnout Research, Elsevier BV, Vol. 3, No. 3 ( 2016-09), p. 63-68
    Type of Medium: Online Resource
    ISSN: 2213-0586
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 2800285-4
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  • 8
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2017
    In:  Journal of Medical Case Reports Vol. 11, No. 1 ( 2017-12)
    In: Journal of Medical Case Reports, Springer Science and Business Media LLC, Vol. 11, No. 1 ( 2017-12)
    Type of Medium: Online Resource
    ISSN: 1752-1947
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2269805-X
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  • 9
    In: Stress, Informa UK Limited, Vol. 19, No. 2 ( 2016-03-03), p. 168-174
    Type of Medium: Online Resource
    ISSN: 1025-3890 , 1607-8888
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2030639-8
    SSG: 12
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  • 10
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  Geriatric Orthopaedic Surgery & Rehabilitation Vol. 9 ( 2018-01-01), p. 215145851875619-
    In: Geriatric Orthopaedic Surgery & Rehabilitation, SAGE Publications, Vol. 9 ( 2018-01-01), p. 215145851875619-
    Abstract: To determine whether any strength, range of motion (ROM), or functional improvement exists in the adductor canal block (ACB) group after completion of inpatient rehabilitation and following the removal of the continuous block. Design: Retrospective cohort. Setting: Inpatient rehabilitation at discharge and outpatient orthopedic clinic for follow-up. Participants: Two hundred forty-six consecutive primary total knee arthroplasties (TKAs; N = 221 patients) performed by a single surgeon in a single institution between July 2013 and August 2015 for a diagnosis of osteoarthritis. Interventions: All TKA cases received a continuous femoral nerve block (FNB) from July 2013 to August 2014 for postoperative pain control. From August 2014 through August 2015, all TKAs received a continuous ACB. Main Outcome Measures: Manual muscle tests (MMTs; 0-5 scale) of the quadriceps and passive ROM of the knee were assessed at 3 time periods (hospital discharge [HD], 1-2 weeks, and 1 month). Patient-oriented outcomes and clinical knee scores were examined preoperatively and postoperatively at 3 and 6 months. Results: 63.6% of FNB cases had an MMT less than 3 at HD and 36.4% of FNB cases had an MMT of 3 or greater at HD. Conversely, 46% of ACB cases had an MMT less than 3 at HD and 54% had an MMT of 3 or greater at HD. There were no statistically significant differences in all postoperative variables at all tested time periods. Conclusions: This study showed no short-term postoperative advantages in the ACB group after catheter removal. The superior inpatient rehabilitation course in the continuous ACB group is likely not long enough to translate into any maintained benefit following catheter removal. Nevertheless, the trend toward greater strength in the ACB group in the immediate short term at HD warrants further investigation.
    Type of Medium: Online Resource
    ISSN: 2151-4593 , 2151-4593
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2589094-3
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