In:
Future Oncology, Future Medicine Ltd, Vol. 1, No. 5 ( 2005-10), p. 649-660
Abstract:
The E-cadherin–β−catenin complex plays a pivotal role in epithelial cell–cell adhesion and in the maintenance of differentiated adult epithelia. Perturbation of its expression or function is widely involved in tumor progression and metastasis. Recent years have seen a rapid expansion in the understanding of the biology and the clinical relevance of the E-cadherin adhesion complex in human lung cancer. During human lung cancer progression genomic, transcriptionnal and post-transcriptionnal alterations of the E-cadherin–β-catenin adhesion system are implicated and comprise deletion of the chromosomic region 3p21 that comprise the locus of the gene encoding β-catenin, transcriptionnal downregulation of E-cadherin, cytoplasmic redistribution, phosphorylation of both proteins and proteolysis of E-cadherin. E-cadherin-inactivating mutations and oncogenic-activating mutation of β-catenin are not reported.
Type of Medium:
Online Resource
ISSN:
1479-6694
,
1744-8301
DOI:
10.2217/14796694.1.5.649
Language:
English
Publisher:
Future Medicine Ltd
Publication Date:
2005
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