In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 1 ( 2021-1-25), p. e0245927-
Abstract:
Acute hypoxemic respiratory failure (AHRF) with bilateral opacities causes fatalities in the intensive care unit (ICU). It is often difficult to identify the causes of AHRF at the time of admission. The SpO 2 to FiO 2 (S/F) ratio has been recently used as a non-invasive and alternative marker of the PaO 2 /FiO 2 (P/F) ratio in acute respiratory failure. This retrospective cohort study was conducted from October 2010 to March 2019 at the Showa University Hospital, Tokyo, Japan. We enrolled 94 AHRF patients who had bilateral opacities and received mechanical ventilation in ICU to investigate their prognostic markers including S/F ratio. Significant differences were observed for APACHE II, S/F ratio, PaO 2 /FiO 2 (P/F) ratio, and ventilator−free-days at day 28 for ICU mortality, and for age, S/F ratio, P/F ratio, duration of mechanical ventilation, and ventilator−free days at day 28 for hospital mortality. Multivariate logistic regression analysis showed that the S/F ratio was significantly and independently associated with the risk of death during in ICU (p = 0.003) and hospitalization (p = 0.002). The area under the receiver operating characteristic curves (AUC) based on the S/F ratio were significantly greater than those based on simplified acute physiology score (SAPS) II and sequential organ failure assessment (SOFA) for ICU mortality (0.785 in S/F ratio vs. 0.575 in SAPS II, p = 0.012; 0.785 in S/F ratio vs 0.594 in SOFA, p = 0.021) and for hospital mortality (0.701 in S/F ratio vs. 0.502 in SAPS II, p = 0.012; 0.701 in S/F ratio vs. 0.503 in SOFA, p = 0.005). In the subanalysis for bacterial pneumonia and interstitial lung disease groups, the AUC based on the S/F ratio was the greatest among all prognostic markers, including APACHE II, SAPS II, and SOFA. The S/F ratio may be a useful and noninvasive predictive prognostic marker for acute hypoxemic respiratory failure with bilateral opacities in the ICU.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0245927
DOI:
10.1371/journal.pone.0245927.g001
DOI:
10.1371/journal.pone.0245927.g002
DOI:
10.1371/journal.pone.0245927.g003
DOI:
10.1371/journal.pone.0245927.g004
DOI:
10.1371/journal.pone.0245927.t001
DOI:
10.1371/journal.pone.0245927.t002
DOI:
10.1371/journal.pone.0245927.t003
DOI:
10.1371/journal.pone.0245927.s001
DOI:
10.1371/journal.pone.0245927.s002
DOI:
10.1371/journal.pone.0245927.r001
DOI:
10.1371/journal.pone.0245927.r002
DOI:
10.1371/journal.pone.0245927.r003
DOI:
10.1371/journal.pone.0245927.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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