In:
FEBS Letters, Wiley, Vol. 275, No. 1-2 ( 1990-11-26), p. 95-98
Abstract:
The effect of human recombinant platelet‐derived growth factor (PDGF) isoforms, (r)PDGF‐AA, PDGF‐AB and PDGF‐BB, on contractility of rat aortic rings as well as on intercellular free Ca 2+ ([Ca 2+ ] i ), intracellular pH i (pH i ) and thromboxane A 2 (TXA 2 ) formation in cultured vascular smooth muscle cells (VSMC) was examined. PDGF‐BB behaved similar to PDGF‐AB and both have features characteristic of conventional vasocontrictor‐agonists that directly increase [Ca 2+ ] i , activate the Na + /H + exchanger, stimulate the TXA 2 formation, and induced contraction in VSMC whereas PDGF‐AA induced contraction without increasing of [Ca 2+ ] i , pH i , and TXA 2 formation.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(90)81447-V
Language:
English
Publisher:
Wiley
Publication Date:
1990
detail.hit.zdb_id:
1460391-3
SSG:
12
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