In:
Renal Replacement Therapy, Springer Science and Business Media LLC, Vol. 8, No. 1 ( 2022-12)
Abstract:
We experienced that some hemodialysis (HD) patients with coronavirus disease 2019 (COVID-19) exacerbated hypoxemia during HD. Though HD-induced hypoxemia has been reported, there have been no reports of HD-induced hypoxemia in patients with COVID-19 and its effect on prognosis of COVID-19. Methods Eleven HD patients admitted with COVID-19 from August 2020 to April 2021 were classified into the patients whose oxygen demand increased by more than 3 L/min with mask during HD (worsened group, n = 5) and others (not-worsened group, n = 6). The background, laboratory findings, severity of COVID-19 and prognosis were compared between the two groups. In addition, blood gases were measured before and after dialysis among HD patients admitted with COVID-19 on April 2021 ( n = 3). Results There were no significant differences in backgrounds, except for a higher proportion of diabetes mellitus in worsened group ( p = 0.04). Although laboratory findings were not significantly different on admission day, albumin and LDH levels 7 days after admission were significantly lower and higher in worsened group, respectively ( p = 0.03 and 〈 0.01). The severity of COVID-19 and survival rate were significantly worse in worsened group ( p = 0.01 and 0.03). The alveolar-arterial oxygen pressure difference (Aa-DO 2 ) opened during HD in a patient with HD-induced hypoxemia, but did not open in patients without HD-induced hypoxemia. Conclusions There is a close relationship among HD-induced hypoxemia and poor prognosis of COVID-19. The HD-induced hypoxemia of patients with COVID-19 may be caused by ventilation/perfusion mismatching.
Type of Medium:
Online Resource
ISSN:
2059-1381
DOI:
10.1186/s41100-022-00408-5
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2022
detail.hit.zdb_id:
2866852-2
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