In:
Cancer Medicine, Wiley, Vol. 5, No. 11 ( 2016-11), p. 3336-3345
Abstract:
Autophagy has been linked with melanoma risk and survival, but no polymorphisms in autophagy‐related ( ATG ) genes have been investigated in relation to melanoma progression. We examined five single‐nucleotide polymorphisms ( SNP s) in three ATG genes ( ATG 5 ; ATG 10 ; and ATG 16L ) with known or suspected impact on autophagic flux in an international population‐based case–control study of melanoma. DNA from 911 melanoma patients was genotyped. An association was identified between ( GG ) (rs2241880) and earlier stage at diagnosis ( OR 0.47; 95% Confidence Intervals ( CI ) = 0.27–0.81, P = 0.02) and a decrease in Breslow thickness ( P = 0.03). The ATG 16L heterozygous genotype ( AG ) (rs2241880) was associated with younger age at diagnosis ( P = 0.02). Two SNP s in ATG 5 were found to be associated with increased stage (rs2245214 CG , OR 1.47; 95% CI = 1.11–1.94, P = 0.03; rs510432 CC , OR 1.84; 95% CI = 1.12–3.02, P = 0.05). Finally, we identified inverse associations between ATG 5 ( GG rs2245214) and melanomas on the scalp or neck ( OR 0.20, 95% CI = 0.05–0.86, P = 0.03); ATG 10 ( CC ) (rs1864182) and brisk tumor infiltrating lymphocytes ( TIL s) ( OR 0.42; 95% CI = 0.21–0.88, P = 0.02), and ATG 5 ( CC ) (rs510432) with nonbrisk TIL s ( OR 0.55; 95% CI = 0.34–0.87, P = 0.01). Our data suggest that ATG SNP s might be differentially associated with specific host and tumor characteristics including age at diagnosis, TIL s, and stage. These associations may be critical to understanding the role of autophagy in cancer, and further investigation will help characterize the contribution of these variants to melanoma progression.
Type of Medium:
Online Resource
ISSN:
2045-7634
,
2045-7634
DOI:
10.1002/cam4.2016.5.issue-11
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2659751-2
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