In:
BMC Anesthesiology, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2006-12)
Abstract:
This animal study was conducted to assess the combined effects of high frequency oscillatory ventilation (HFOV) and prone positioning on pulmonary gas exchange and hemodynamics. Methods Saline lung lavage was performed in 14 healthy pigs (54 ± 3.1 kg, mean ± SD) until the arterial oxygen partial pressure (PaO 2 ) decreased to 55 ± 7 mmHg. The animals were ventilated in the pressure controlled mode (PCV) with a positive endexpiratory pressure (PEEP) of 5 cmH 2 O and a tidal volume (V T ) of 6 ml/kg body weight. After a stabilisation period of 60 minutes, the animals were randomly assigned to 2 groups. Group 1: HFOV in supine position; group 2: HFOV in prone position. After evaluation of prone positioning in group 2, the mean airway pressure (P mean ) was increased by 3 cmH 2 O from 16 to 34 cmH 2 O every 20 minutes in both groups accompanied by measurements of respiratory and hemodynamic variables. Finally all animals were ventilated supine with PCV, PEEP = 5 cm H 2 O, V T = 6 ml/kg. Results Combination of HFOV with prone positioning improves oxygenation and results in normalisation of cardiac output and considerable reduction of pulmonary shunt fraction at a significant (p 〈 0.05) lower P mean than HFOV and supine positioning. Conclusion If ventilator induced lung injury is ameliorated by a lower P mean , a combined treatment approach using HFOV and prone positioning might result in further lung protection.
Type of Medium:
Online Resource
ISSN:
1471-2253
DOI:
10.1186/1471-2253-6-4
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2006
detail.hit.zdb_id:
2091252-3
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