In:
Science, American Association for the Advancement of Science (AAAS), Vol. 302, No. 5645 ( 2003-10-24), p. 659-662
Abstract:
Spontaneous resolution of hepatitis C virus (HCV) infection in humans usually affords long-term immunity to persistent viremia and associated liver diseases. Here, we report that memory CD4 + Tcells are essential for this protection. Antibody-mediated depletion of CD4 + Tcells before reinfection of two immune chimpanzees resulted in persistent, low-level viremia despite functional intra-hepatic memory CD8 + Tcell responses. Incomplete control of HCV replication by memory CD8 + Tcells in the absence of adequate CD4 + Tcell help was associated with emergence of viral escape mutations in class I major histocompatibility complex–restricted epitopes and failure to resolve HCV infection.
Type of Medium:
Online Resource
ISSN:
0036-8075
,
1095-9203
DOI:
10.1126/science.1088774
Language:
English
Publisher:
American Association for the Advancement of Science (AAAS)
Publication Date:
2003
detail.hit.zdb_id:
128410-1
detail.hit.zdb_id:
2066996-3
detail.hit.zdb_id:
2060783-0
SSG:
11
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