In:
EMBO Molecular Medicine, EMBO, Vol. 9, No. 7 ( 2017-07), p. 859-868
Abstract:
image The C9orf72 hexanucleotide repeat expansion causing amyotrophic lateral sclerosis and frontotemporal dementia is translated into five dipeptide repeat (DPR) proteins, including poly‐GP. Analysis of poly‐GP levels in the CSF of patients and presymptomatic carriers support an early role of DPRs in pathogenesis. Monoclonal immunoassay detects poly‐GP in CSF of C9orf72 patients. Poly‐GP levels in asymptomatic carriers and c9ALS/FTD patients are similar. Neurofilaments but not poly‐GP levels correlate with clinical disease progression.
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.15252/emmm.201607486
Language:
English
Publisher:
EMBO
Publication Date:
2017
detail.hit.zdb_id:
2485479-7
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