In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 35, No. 1 ( 2012-01), p. 86-94
Abstract:
To assess the clinical value of oxygen‐enhanced magnetic resonance imaging (oeMRI) in patients with pulmonary hypertension (PH) by correlation with ventilation/perfusion (V/Q) scintigraphy. Materials and Methods: In all, 33 patients with known PH underwent V/Q scintigraphy and oeMRI. oeMRI was used to assess the regional pulmonary function based on relative‐signal‐enhancement (RSE) and cross‐correlation‐coefficient (CCC) maps, evaluating mean RSE (mRSE), fraction of oxygen‐activated pixels (fOAP), and mean CCC (mCCC). Two reviewers, blinded to the results of scintigraphy, performed visual detection of diseased lung areas. Results: In 26 of the 33 patients (79%) the image quality of oeMRI reached a diagnostic level. In total, 150 lung areas were analyzed and compared. Sensitivities/specificities of oeMRI for detecting these defects were: RSE vs. ventilation scintigraphy 92%/73%; RSE vs. perfusion scintigraphy 60%/87%; CCC vs. ventilation scintigraphy 89%/81%; CCC vs. perfusion scintigraphy 50%/87%. The number of diseased lung areas in oeMRI correlated significantly with the number in V/Q scintigraphy ( P 〈 0.01). mRSE showed a significant correlation with the number of diseased lung areas in ventilation scintigraphy ( P 〈 0.05). Conclusion: oeMRI is feasible in PH patients, yielding an overall moderate agreement between oeMRI and V/Q scans, with a good sensitivity of oeMRI for the detection of ventilation defects as compared with ventilation scintigraphy. J. Magn. Reson. Imaging 2012;35:86‐94. © 2011 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
1053-1807
,
1522-2586
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
1497154-9
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