In:
TECHNOLOGY, World Scientific Pub Co Pte Ltd, Vol. 02, No. 01 ( 2014-03), p. 28-35
Abstract:
Cryoablation is a promising minimally invasive technology for cancer treatment. However, no study was reported concerning the effect of cryoablation on cancer stem-like cells (CSCs) that are capable of reinitiating tumor growth after conventional chemotherapy. Using a biomimetic 3D mammosphere model, we found that cryoablation alone could significantly but incompletely destroy CD44 + CD133 + CSCs. Moreover, the combination of cryoablation and conventional chemotherapy using free doxorubicin (fDOX) does not significantly enhance destruction of the CSCs over the individual treatments. We develop a novel combined treatment of cryoablation and nanoparticle-encapsulated doxorubicin (nDOX) that is capable of achieving nearly complete elimination of the CSCs (from 16.6 to 0.6%). This is attributed in part to the much-enhanced uptake of nDOX (compared to fDOX) by the CSCs. Collectively, this study demonstrates the great potential of a combined therapy of cryoablation and nanodrug for improved cancer treatment by eliminating the root of cancer — the CSCs.
Type of Medium:
Online Resource
ISSN:
2339-5478
,
2345-7740
DOI:
10.1142/S2339547814500022
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
2014
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