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  • Wiley  (5)
  • Rao, Roopa S.  (5)
  • 1
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    Online Resource
    Immunohistochemical expression of Tazarotene‐induced Gene 3 in oral squamous cell carcinoma
    Wiley ; 2021
    In:  Journal of Oral Pathology & Medicine Vol. 50, No. 4 ( 2021-04), p. 403-409
    Details
    In: Journal of Oral Pathology & Medicine, Wiley, Vol. 50, No. 4 ( 2021-04), p. 403-409
    Abstract: The prognosis of hyperproliferative skin lesions, such as psoriasis, basal cell carcinoma, and non‐melanoma skin cancers, is significantly benefited from the levels of tazarotene‐induced gene‐1 (TIG3) expression and subsequent treatment with tazarotene. Such observations suggest that TIG3 could be used as a biomarker for apoptosis, differentiation, and proliferation. The current study aimed to evaluate the expression of TIG3 in normal oral mucosa (NOM) and oral squamous cell carcinoma (OSCC) compared with normal skin (NS) and skin squamous cell carcinoma (SSCC) using immunohistochemistry. Methods Seventeen cases each of SSCC, OSCC, NOM, and NS were evaluated. Each section was immunohistochemically stained with a rabbit polyclonal TIG3 antibody. The entire procedure was blinded and evaluated by 5 observers. Statistical analysis was performed using the chi‐square test. Results There was a significant decrease in TIG3 protein expression in OSCC and SSCC compared with that in NOM and NS ( P  = 0.008). The progressive loss of expression was observed as the grade of both malignancies increased. However, there was no significant difference in the expression among the normal tissue groups and within SCC groups of similar grades. Conclusion The present study suggests that the loss of TIG3 is an important event in carcinogenesis. TIG3 acts as a regulator of keratinocyte proliferation and terminal differentiation. Therefore, TIG3 could be a potential biomarker to differentiate aggressive and non‐aggressive neoplasms.
    Type of Medium: Online Resource
    ISSN: 0904-2512 , 1600-0714
    URL: Issue
    URL: Article
    DOI: 10.1111/jop.v50.4
    DOI: 10.1111/jop.13144
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2026385-5
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  • 2
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    Exophytic oral verrucous hyperplasia: a new entity
    Wiley ; 2016
    In:  Journal of Investigative and Clinical Dentistry Vol. 7, No. 4 ( 2016-11), p. 417-423
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    In: Journal of Investigative and Clinical Dentistry, Wiley, Vol. 7, No. 4 ( 2016-11), p. 417-423
    Abstract: Exophytic oral verrucous hyperplasia ( OVH ) is a new entity described by an expert working group from South Asia. First reported in Taiwan, there are no reports so far from an Indian population. The aim was to use the microscopic features described by the expert group to differentiate OVH from other oral verruco‐papillary lesions in an Indian archive. Materials and methods In a retrospective multicentre study, using pathology archives, 188 verruco‐papillary lesions were retrieved from pathology archives. A proforma listing histopathological criteria for OVH based on published guidelines (Annals of Dentistry, University of Malaya, 2013) was used. Patients’ demographic and clinical data were transcribed from patient charts. The Pearson chi‐square test was used to determine associations between clinical and histopathological features. Results Of 188 oral verruco‐papillary lesions that were evaluated, based on microscopic features the cases were reclassified as OVH (57), verrucous carcinoma (VC) (84), oral squamous cell carcinoma (16), and other verruco‐papillary lesions (31). Both OVH (70%) and VC (60%) showed male predominance and commonly affected buccal mucosa ( OVH 74% and VC 57%). Absence of downward growth of the hyperplastic epithelium into lamina propria when compared with the level of the basement membrane of the adjacent normal epithelium was a distinct feature in OVH . Keratin plugging, epithelial dysplasia and subepithelial lymphocytic infiltration were found to be significantly different ( P   〈  0.05) in OVH versus VC . The sample size of other verruco‐papillary lesions was insufficient for statistical comparison. Conclusion Apart from the absence of an endophytic growth pattern in OVH , we noted the presence of dysplasia in OVH . This significant observation does institute a debate as to whether this enigmatic lesion could possibly be a precedent of oral squamous or verrucous carcinoma. We propose OVH is a distinct entity in our Indian population and should be considered in the classification of oral potentially malignant disorders.
    Type of Medium: Online Resource
    ISSN: 2041-1618 , 2041-1626
    URL: Issue
    URL: Article
    DOI: 10.1111/jicd.2016.7.issue-4
    DOI: 10.1111/jicd.12166
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2568292-1
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  • 3
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    Lichenoid dysplasia revisited – evidence from a review of Indian archives
    Wiley ; 2015
    In:  Journal of Oral Pathology & Medicine Vol. 44, No. 7 ( 2015-08), p. 507-514
    Details
    In: Journal of Oral Pathology & Medicine, Wiley, Vol. 44, No. 7 ( 2015-08), p. 507-514
    Abstract: To report on the prevalence of ‘lichenoid dysplasia’ ( LD ) in oral mucosal biopsies previously reported as oral lichen planus ( OLP ), oral lichenoid lesion ( OLL ) and oral epithelial dysplasia ( OED ). Based on this case series, to postulate whether features of dysplasia are present in biopsies with a diagnosis of OLP or OLL and vice versa that warrant a separate diagnostic entity of ‘lichenoid dysplasia’. Material and methods This retrospective, multicentre study was carried out by retrieving archival slides of cases diagnosed with OLP , OLL and OED . Diagnostic criteria for the study were based on published guidelines from seminal papers. A total of 165 cases, 70 OLP and OLL and 95 epithelial dysplasia cases, were re‐examined. The diagnosis of OLP s and OLL s was first reconfirmed according to published diagnostic criteria. They were then verified for microscopic features of epithelial dysplasia. Among cases of leukoplakia diagnosed with epithelial dysplasia, we further verified for the presence of lichenoid features. Results A total of 70 cases of OLP and OLL were microscopically evaluated ( OLP ‐54; OLL ‐16). Epithelial dysplasia was noted in 11 cases ( OLP – 8 of 54; OLL – 3 of 16). Nineteen cases of OLP (19 of 54) were found to bear features of OLL s as per published diagnostic criteria. Among the OED group, 22 of the 95 cases showed lichenoid features. Conclusion The study confirms lichenoid features may be found in OED s and epithelial dysplasia may be found in OLP / OLL . We reconfirm that these microscopic features may coexist. Our findings require further discussion by a panel of experts to redefine the entity known as ‘lichenoid dysplasia’. Future studies should address the concept of lichenoid dysplasia that may assist to resolve any controversies with regard to the malignant potential of OLP .
    Type of Medium: Online Resource
    ISSN: 0904-2512 , 1600-0714
    URL: Issue
    URL: Article
    DOI: 10.1111/jop.2015.44.issue-7
    DOI: 10.1111/jop.12258
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2026385-5
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  • 4
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    Estimating the frequency of Candida in oral squamous cell carcinoma using Calcofluor White fluorescent stain
    Wiley ; 2016
    In:  Journal of Investigative and Clinical Dentistry Vol. 7, No. 3 ( 2016-08), p. 304-307
    Details
    In: Journal of Investigative and Clinical Dentistry, Wiley, Vol. 7, No. 3 ( 2016-08), p. 304-307
    Abstract: To determine the frequency of Candida in oral squamous cell carcinoma ( OSCC ) using Calcofluor White ( CFW ) fluorescent stain and to evaluate the association of the same in different grades of OSCC . Methods One hundred archival formalin fixed paraffin embedded tissues of diagnosed cases of OSCC were retrieved. The samples comprised of 81, 18 and 1 case of well, moderately, and poorly differentiated squamous cell carcinomas ( WSCC , MSCC , PSCC ) respectively. Each section was subjected to staining with CFW fluorescent stain for the detection of frequency of candidal hyphae. A chi square test was used to compare the proportion of occurrence of candidal hyphae between different grades of OSCC . Results Ten of the 100 cases of OSCC s stained positive for Candida with CFW . Positive staining for Candida was seen in six out of 81 and four out of 18 cases of WSCC s and MSCC s respectively. The chi square test used for comparison of the proportion of occurrence of candidal hyphae between WSCC and MSCC ( P  = 0.059) and all grades of OSCC ( P  = 0.157) did not yield any statistically significant value. Conclusion The presence of Candida in OSCC solely does not justify its role in carcinogenesis. Further appraisal to evaluate a direct causal role of the micro‐organism in potentially malignant disorders and OSCC is required.
    Type of Medium: Online Resource
    ISSN: 2041-1618 , 2041-1626
    URL: Issue
    URL: Article
    DOI: 10.1111/jicd.2016.7.issue-3
    DOI: 10.1111/jicd.12161
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2568292-1
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  • 5
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    Online Resource
    Expression of type III collagen correlates with poor prognosis in oral squamous cell carcinoma
    Wiley ; 2017
    In:  Journal of Investigative and Clinical Dentistry Vol. 8, No. 4 ( 2017-11)
    Details
    In: Journal of Investigative and Clinical Dentistry, Wiley, Vol. 8, No. 4 ( 2017-11)
    Abstract: The aim of the present study was to evaluate, compare, and correlate the types of collagen fibers seen in different grades of oral cancer. Methods Thirty cases of histologically‐diagnosed, well‐, moderately‐, and poorly‐differentiated oral squamous cell carcinoma ( OSCC ) were retrieved from the archives of the Institute. Collagen was evaluated using picrosirius red stain and immunohistochemical analysis of the antibody to type III collagen. A correlation between these findings and the grade of OSCC was evaluated. Results Collagen fibers showed a change in birefringence ranging from reddish–orange to greenish–yellow in well‐ to poorly‐differentiated oral squamous cell carcinoma. The findings were statistically significant for polarizing colors observed in grades of OSCC ( P 〈 .001). Immunohistochemical staining intensity of type III collagen changed from weak to strong as grade increased for OSCC , and was also statistically significant ( P 〈 .001). Conclusion In the present study, tumor progression reflected a change in collagen present, from type I to type III . Determination of the type of collagen in different grades of OSCC can facilitate therapeutic targeting of molecules responsible for invasion and progression of oral cancer.
    Type of Medium: Online Resource
    ISSN: 2041-1618 , 2041-1626
    URL: Issue
    URL: Article
    DOI: 10.1111/jicd.2017.8.issue-4
    DOI: 10.1111/jicd.12253
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2568292-1
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