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  • 1
    Online Resource
    Online Resource
    Mass Spectrometry-based Alkaloid Profiling of Cyclea peltata Roots and Evaluation of In vitro Cytotoxic Activity
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Bioactive Compounds Vol. 19, No. 6 ( 2023-07)
    Details
    In: Current Bioactive Compounds, Bentham Science Publishers Ltd., Vol. 19, No. 6 ( 2023-07)
    Abstract: Cyclea peltata (Lam.) Hook. f. and Thoms., an ethnomedicinal herb with antitoxin and anti-herpes activities, is used to cure smallpox, wounds, diabetic disorders of the skin, and its use as a cooling agent. In the present study, an attempt has been made to screen different alkaloids present in Cyclea peltata roots using LC-ESI-MS/MS and to evaluate the in vitro cytotoxic activity of alkaloids. Methods: The detection of alkaloids in C. peltata root extract was carried out by performing MRM-based assay using liquid chromatography-mass spectrometry. The cytotoxic effect of the acetone crystalized fraction was performed against human pancreatic cancer using MIA PaCa-2 cells. Results: The study revealed the presence of tetrandrine and fangchinoline as the major BBI alkaloids in the roots of this herb, along with cycleacurine, isochondrodendrine, cycleahomine and tetrandrine mono-N-2’-oxide. Furthermore, the present study also detected two precursors of BBI alkaloids such as d-Coclaurine, (-)-N-methylcoclaurine. The study also showed a significant (p 〈 0.05) cytotoxic effect of the acetone crystalized fraction with an IC50 value of 59.85 μg/ml. Conclusion: C. peltata root is the major source of tetrandrine and fangchinoline with potent cytotoxic effect.
    Type of Medium: Online Resource
    ISSN: 1573-4072
    URL: Article
    DOI: 10.2174/1573407219666221201103555
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Green synthesis of zinc oxide nanoparticles from the leaf, stem and in vitro grown callus of Mussaenda frondosa L.: characterization and their applications
    Springer Science and Business Media LLC ; 2020
    In:  Applied Nanoscience Vol. 10, No. 8 ( 2020-08), p. 3057-3074
    Details
    In: Applied Nanoscience, Springer Science and Business Media LLC, Vol. 10, No. 8 ( 2020-08), p. 3057-3074
    Type of Medium: Online Resource
    ISSN: 2190-5509 , 2190-5517
    URL: Article
    DOI: 10.1007/s13204-020-01382-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2607723-1
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  • 3
    Online Resource
    Online Resource
    Antiviral, Anticancer and Hypotensive Potential of Diphyllin Glycosides and their Mechanisms of Action
    Bentham Science Publishers Ltd. ; 2022
    In:  Mini-Reviews in Medicinal Chemistry Vol. 22, No. 13 ( 2022-07), p. 1752-1771
    Details
    In: Mini-Reviews in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 22, No. 13 ( 2022-07), p. 1752-1771
    Abstract: Diphyllin glycosides (DG) are a type of arylnaphthalene lignans isolated from different plants, and their synthetic derivatives have shown effective antiviral, cytotoxic, hypotensive and diuretic effects at very low concentrations similar to standard drugs that are under clinical use. The biological activities of the DG interfere with signaling pathways of viral infection and cancer induction. The sugar moieties of DG enhance bioavailability and pharmacological activities. The promising results of DG at nanomolar concentrations under in vitro and in vivo conditions should be explored further with clinical trials to determine its toxic effects, pharmacokinetics and pharmacodynamics. This may help identify suitable antiviral and anticancer drugs in the near future. Considering all these activities, the present review is focused on the chemical aspects of DG with a detailed account of the mechanisms of action of DG. An attempt is also made to comment on the status of clinical trials involving DG along with the possible limitations in studies based on available literature till September 2020.
    Type of Medium: Online Resource
    ISSN: 1389-5575
    URL: Article
    DOI: 10.2174/1389557522666220117122718
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Bioassay-guided Isolation and Identification of Antidiabetic Compounds from Naregamia alata
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Bioactive Compounds Vol. 19, No. 9 ( 2023-11)
    Details
    In: Current Bioactive Compounds, Bentham Science Publishers Ltd., Vol. 19, No. 9 ( 2023-11)
    Abstract: Naregamia alata is an endemic herb of Western Ghats with traditional medicinal uses and pharmacological activities, viz. anti-inflammatory, antioxidant, antipyretic, hepatoprotective and antidiabetic effects. However, no information is available on the phyto-constituents of N. alata responsible for antidiabetic activities. Objective: Isolation and identification of compound/s from the dichloromethane fraction of methanol extract of N. alata and to confirm the antidiabetic activity using streptozotocin induced diabetic rat models. Methods: The DCM fraction obtained from the methanol extract of N. alata was fractionated using column chromatography. The fractions with in vivo antidiabetic activity were characterised chemically using GCMS, FTIR, and 1H NMR to identify the phytochemicals responsible for the antidiabetic activities. Results: The study showed the antidiabetic effect of DCM fraction with the regulation of serum biochemical parameters. The chemical characterisation of the fractions responsible for the in vivo antidiabetic effect revealed the presence of hexadecanoic acid methyl ester and 13-docosenamide as two major compounds in one of the fractions (Fraction 1) and citronellol in another fraction (Fraction 2.2.1). Conclusion: The study highlights the role of hexadecanoic acid methyl ester, 13-docosenamide and citronellol in a reversal of serum biochemical parameters along with body weight in streptozotocin-induced diabetic rats to near normal suggesting the potential antidiabetic properties of these compounds.
    Type of Medium: Online Resource
    ISSN: 1573-4072
    URL: Article
    DOI: 10.2174/1573407219666230413081819
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
    Location Call Number Limitation Availability
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    Online Resource
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