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  • 1
    Online Resource
    Online Resource
    Prognostic Factors after Percutaneous Radiofrequency Ablation in the Treatment of Hepatocellular Carcinoma. Impact of Incomplete Ablation on Recurrence and Overall Survival Rates
    Romanian Society of Gastroenterology and Hepatology ; 2018
    In:  Journal of Gastrointestinal and Liver Diseases Vol. 27, No. 4 ( 2018-12-31), p. 399-407
    Details
    In: Journal of Gastrointestinal and Liver Diseases, Romanian Society of Gastroenterology and Hepatology, Vol. 27, No. 4 ( 2018-12-31), p. 399-407
    Abstract: Aims: To report on the long-term impact of tumor and non-tumor related parameters on local recurrence, distant recurrence and survival in patients with naïve or recurrent type hepatocellular carcinoma (HCC) treated by radiofrequency ablation (RFA).Methods: We performed 240 RFA sessions on 133 patients with 156 HCC nodules developed on a background of liver cirrhosis and analyzed the outcomes.Results: Contrast-enhanced ultrasound performed one month after RFA showed complete ablation in 119 out of 133 (89.65%) patients. With a median follow-up of 46 months, 3-, 5- and 7-year survival rates were 61.7%, 35.7%, and 22.6%, respectively. Previous ethanol injection and histological grade were significantly related to local tumor progression. Child-Pugh class, incomplete ablation, histological grade, previous ethanol injection, alpha-fetoprotein level before the treatment, and local recurrence were all significantly related to distant recurrence. Multivariate analysis demonstrated that age, Child-Pugh class, distant recurrence and multiple incomplete ablations were significantly related to survival.Conclusion: Radiofrequency ablation could be locally curative for HCC, resulting in a survival longer than 7 years. Previous ethanol injection and incomplete ablations were strongly associated with poor outcomes.
    Type of Medium: Online Resource
    ISSN: 1842-1121 , 1841-8724
    URL: Article
    DOI: 10.15403/jgld.2014.1121.274.pro
    Language: Unknown
    Publisher: Romanian Society of Gastroenterology and Hepatology
    Publication Date: 2018
    detail.hit.zdb_id: 2253255-9
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  • 2
    Online Resource
    Online Resource
    Microwave ablation in the treatment of liver tumors. A better tool or simply more power?
    SRUMB - Romanian Society for Ultrasonography in Medicine and Biology ; 2020
    In:  Medical Ultrasonography Vol. 22, No. 4 ( 2020-11-18), p. 451-
    Details
    In: Medical Ultrasonography, SRUMB - Romanian Society for Ultrasonography in Medicine and Biology, Vol. 22, No. 4 ( 2020-11-18), p. 451-
    Abstract: It has been a long time since tumor ablation was first tested in patients with liver cancer, especially hepatocellular carcinoma. Since than it has become a first line treatment modality for hepatocellular carcinoma. Over the years, the indications of thermal ablation have expanded to colorectal cancer liver metastases and intrahepatic cholangiocarcinoma as well. Together with the new indication for ablation, new ablation devices have been developed as well. Among them microwave ablation shows potential in replacing radiofrequency ablation as the preferred method of thermal ablation in liver cancer. The debate whether radiofrequency or microwave ablation should be the preferred method of treatment in patients with liver cancer remains open. The main purpose of this review is to offer some answers to the question: Microwave ablation in liver tumors: a better tool or simply more power? Various clinical scenarios will be analyzed including small, medium, and intermediate size hepatocellular carcinoma, colorectal cancer liver metastases and intrahepatic cholangiocarcinoma. Furthermore, the advantages, limitations, and technical considerations of MWA treatment will be provided also.
    Type of Medium: Online Resource
    ISSN: 2066-8643 , 1844-4172
    URL: Article
    DOI: 10.11152/mu-2556
    Language: Unknown
    Publisher: SRUMB - Romanian Society for Ultrasonography in Medicine and Biology
    Publication Date: 2020
    detail.hit.zdb_id: 2529623-1
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  • 3
    Online Resource
    Online Resource
    Contrast enhanced ultrasonography in assessing the treatment response to transarterial chemoembolization in patients with hepatocellular carcinoma.
    SRUMB - Romanian Society for Ultrasonography in Medicine and Biology ; 2016
    In:  Medical Ultrasonography Vol. 18, No. 1 ( 2016-03-01), p. 96-
    Details
    In: Medical Ultrasonography, SRUMB - Romanian Society for Ultrasonography in Medicine and Biology, Vol. 18, No. 1 ( 2016-03-01), p. 96-
    Abstract: Abstract. The last decades have known continuous development of therapeutic strategies in hepatocellular carcinoma (HCC). Unfortunately the disease it still not diagnosed until it is already at an intermediate or even an advanced disease. In these circumstances transarterial chemoembolization (TACE) is considered an effective treatment for HCC. The most important independent prognostic factor of both disease free survival and overall survival is the presence of complete necrosis. Therefore, treatment outcomes are dictated by the proper use of radiological imaging. Current guidelines recommend contrast enhanced computer tomography (CECT) as the standard imaging technique for evaluating the therapeutic response in patients with HCC after TACE. One of the most important disadvantage of CECT is the overestimation of tumor response. As an attempt to overcome this limitation contrast enhanced ultrasound (CEUS) has gained particular attention as an imaging modality in HCC patients after TACE. Of all available imaging modalities, CEUS performs better in the early and very early assessment of TACE especially after lipiodol TACE. As any other imaging techniques CEUS has disadvantages especially in hypovascular tumors or in cases of tumor multiplicity. Not far from now the current limitations of CEUS will be overcome by the new CEUS techniques that are already tested in clinical practice such as dynamic CEUS with quantification, three-dimensional CEUS or fusion techniques.
    Type of Medium: Online Resource
    ISSN: 2066-8643 , 1844-4172
    URL: Article
    DOI: 10.11152/mu.2013.2066.181.scz
    Language: Unknown
    Publisher: SRUMB - Romanian Society for Ultrasonography in Medicine and Biology
    Publication Date: 2016
    detail.hit.zdb_id: 2529623-1
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  • 4
    Online Resource
    Online Resource
    Combined treatments in hepatocellular carcinoma: Time to put them in the guidelines?
    Baishideng Publishing Group Inc. ; 2021
    In:  World Journal of Gastrointestinal Oncology Vol. 13, No. 12 ( 2021-12-15), p. 1896-1918
    Details
    In: World Journal of Gastrointestinal Oncology, Baishideng Publishing Group Inc., Vol. 13, No. 12 ( 2021-12-15), p. 1896-1918
    Type of Medium: Online Resource
    ISSN: 1948-5204
    URL: Article
    DOI: 10.4251/wjgo.v13.i12.1896
    Language: Unknown
    Publisher: Baishideng Publishing Group Inc.
    Publication Date: 2021
    detail.hit.zdb_id: 2573696-6
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