In:
Infection and Immunity, American Society for Microbiology, Vol. 73, No. 1 ( 2005-01), p. 666-670
Abstract:
We compared the growth levels and pathogenicities of the Mycobacterium tuberculosis MT103 clinical strain with those of the Δ purC mutant strain MYC1551, which is auxotrophic for purine in wild-type and gamma interferon receptor (IFN-γR)-deficient mice. The Δ purC strain MYC1551 grew initially in both wild-type and IFN-γR-deficient mice upon aerosol infection, but it grew much less than strain MT103 did. Despite the comparable bacterial burdens of the mice, IFN-γR-deficient mice succumbed to infection with Δ purC strain MYC1551 from necrotic pneumonia within 6 weeks of those infected with MT103. In conclusion, the Δ purC mutant MYC1551 displays reduced growth but retains pathogenicity. Therefore, the use of mutant strains of M. tuberculosis as live vaccines may not be recommended.
Type of Medium:
Online Resource
ISSN:
0019-9567
,
1098-5522
DOI:
10.1128/IAI.73.1.666-670.2005
Language:
English
Publisher:
American Society for Microbiology
Publication Date:
2005
detail.hit.zdb_id:
1483247-1
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