In:
PLOS Neglected Tropical Diseases, Public Library of Science (PLoS), Vol. 15, No. 11 ( 2021-11-17), p. e0009943-
Abstract:
B cells played an important role in Schistosoma infection-induced diseases. TLR7 is an intracellular member of the innate immune receptor. The role of TLR7 on B cells mediated immune response is still unclear. Here, C57BL/6 mice were percutaneously infected by S . japonicum for 5–6 weeks. The percentages and numbers of B cells increased in the infected mice ( p 〈 0.05), and many activation and function associated molecules were also changed on B cells. More splenic cells of the infected mice expressed TLR7, and B cells were served as the main cell population. Moreover, a lower level of soluble egg antigen (SEA) specific antibody and less activation associated molecules were found on the surface of splenic B cells from S . japonicum infected TLR7 gene knockout (TLR7 KO) mice compared to infected wild type (WT) mice ( p 〈 0.05). Additionally, SEA showed a little higher ability in inducing the activation of B cells from naive WT mice than TLR7 KO mice ( p 〈 0.05). Finally, the effects of TLR7 on B cells are dependent on the activation of NF-κB p65. Altogether, TLR7 was found modulating the splenic B cell responses in S . japonicum infected C57BL/6 mice.
Type of Medium:
Online Resource
ISSN:
1935-2735
DOI:
10.1371/journal.pntd.0009943
DOI:
10.1371/journal.pntd.0009943.g001
DOI:
10.1371/journal.pntd.0009943.g002
DOI:
10.1371/journal.pntd.0009943.g003
DOI:
10.1371/journal.pntd.0009943.g004
DOI:
10.1371/journal.pntd.0009943.g005
DOI:
10.1371/journal.pntd.0009943.g006
DOI:
10.1371/journal.pntd.0009943.g007
DOI:
10.1371/journal.pntd.0009943.s001
DOI:
10.1371/journal.pntd.0009943.s002
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2429704-5
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