In:
Journal of Clinical Psychopharmacology, Ovid Technologies (Wolters Kluwer Health), Vol. 41, No. 3 ( 2021-5), p. 255-259
Abstract:
This study aimed to investigate the combined effects of dose, age, sex, body weight, and smoking on plasma concentrations of olanzapine (OLA) and N-desmethyl olanzapine (DMO) in Chinese inpatients with schizophrenia. Methods A retrospective study including 185 inpatients was conducted. The steady-state plasma concentrations of OLA (C OLA ) and DMO (C DMO ) were measured using high-performance liquid chromatography-tandem mass spectrometry. The combined effects of dose, age, sex, body weight, and smoking on C OLA and C DMO were evaluated. Findings Multiple linear regression analyses revealed that dose, age, body weight, and smoking had significant effects on C OLA and C DMO in inpatients with schizophrenia treated with OLA. The dose was the most important determinant of C OLA and C DMO and was positively correlated with both. Furthermore, smokers exhibited a significantly lower C OLA and C OLA + DMO , whereas higher body weight led to the reduction of C OLA , C DMO , and C OLA + DMO . Advanced age was associated with lower C DMO . Implications These results suggest that dose, age, body weight, and smoking have a significant influence on the plasma concentration of OLA and its metabolite DMO. Clinicians should consider the combined effects when prescribing OLA to patients with schizophrenia.
Type of Medium:
Online Resource
ISSN:
1533-712X
,
0271-0749
DOI:
10.1097/JCP.0000000000001390
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021
detail.hit.zdb_id:
2057059-4
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