In:
Angewandte Chemie, Wiley, Vol. 129, No. 29 ( 2017-07-10), p. 8636-8641
Abstract:
A novel NHC‐catalyzed annulation protocol for the asymmetric synthesis of biologically important β‐lactam fused spirocyclopentane oxindoles with four contiguous stereocenters, including two quaternary carbon centers, was developed. Alternatively, spirocyclopentane oxindoles containing an enaminone moiety can be achieved using the same starting materials, isatin‐derived enals, and N‐sulfonyl ketimines, in the presence of a slightly different NHC catalytic system. This switchable annulation strategy enables the selective assembly of both heterocyclic scaffolds with good yields and excellent enantioselectivities for a broad range of substrates.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v129.29
DOI:
10.1002/ange.201704210
Language:
English
Publisher:
Wiley
Publication Date:
2017
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505868-5
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506609-8
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514305-6
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505872-7
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1479266-7
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505867-3
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506259-7
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