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  • Polonskaia, Aleksandra S.  (4)
  • 1
    Online Resource
    Online Resource
    Evaluation of effectiveness of combined supportive treatment for paronychia and pyogenic granulomas, associated with targeted anticancer therapy
    ECO-Vector LLC ; 2023
    In:  Russian Journal of Skin and Venereal Diseases Vol. 25, No. 6 ( 2023-02-17), p. 41-53
    Details
    In: Russian Journal of Skin and Venereal Diseases, ECO-Vector LLC, Vol. 25, No. 6 ( 2023-02-17), p. 41-53
    Abstract: BACKGROUND: Paronychia and pyogenic granulomas occur in 1050% of patients treated with epidermal growth receptor (EGFR) inhibitors. Supportive therapy for periungual lesions is challenging, since these adverse reactions are prone to torpidity and frequent relapses. AIM: to evaluate the effectiveness of supportive treatment for paronychia and pyogenic granulomas ― dermatologic adverse events of EGFR inhibitors, with a combined cream with betamethasone dipropionate, clotrimazole, gentamicin, and betaxolol solution. MATERIALS AND METHODS: 16 patients with paronychia and pyogenic granulomas associated with EGFR inhibitor therapy were included in a 12-week open-label prospective study. Paronychia and pyogenic granulomas severity assessment was performed with the NCI-CTCAE v. 5.0, a developed 10-point scale. The intensity of pain was assessed with a visual-analogue scale (VAS). The quality of life was assessed with the Dermatology Life Quality Index (DLQI). RESULTS: A significant improvement of all parameters (p 0.05) was evaluated from week 1, indicating the effective reduction of dermatologic adverse event objective and subjective symptoms, improvement of patients quality of life. By the end of the study, 37.5% of patients had complete resolution of lesions, 62.5% of patients had minimal residual erythema. Decrease of pain sensation in the affected periungual folds was observed throughout the study (p 0.05). DLQI score indicated the "small effect" of paronychia and pyogenic granulomas on patients life by the end of the study. CONCLUSIONS: Supportive treatment of paronychia and pyogenic granulomas with a combined cream with betamethasone dipropionate, clotrimazole and gentamicin and a betaxolol 0.25% solution is effective in the management of paronychia and pyogenic granulomas objective and subjective symptoms, has a high tolerability, allows to improve patients quality of life and continue targeted therapy without dose reduction. Long-term maintenance of pain sensation after paronychia and pyogenic granulomas resolution underlines the need for additional treatment options that will improve the effectiveness of pain management.
    Type of Medium: Online Resource
    ISSN: 2412-9097 , 1560-9588
    URL: Issue
    URL: Article
    DOI: 10.17816/dv.256
    DOI: 10.17816/dv112268
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Balneotherapy as a promising method for the correction of dermatologic adverse events of cancer therapy
    ECO-Vector LLC ; 2022
    In:  Russian Journal of Physiotherapy, Balneology and Rehabilitation Vol. 20, No. 6 ( 2022-09-15), p. 551-558
    Details
    In: Russian Journal of Physiotherapy, Balneology and Rehabilitation, ECO-Vector LLC, Vol. 20, No. 6 ( 2022-09-15), p. 551-558
    Abstract: Cancer treatment with chemotherapy, targeted and immunotherapy is associated with a wide spectrum of dermatologic adverse events. Xerosis (dryness) of the skin is the most prevalent skin side effect in oncologic patients, which occurs both during treatment with "classic" chemotherapy drugs and modern cancer drugs, such as targeted therapy and immunotherapy. Despite the high prevalence of this side effect, current approaches to the correction of skin xerosis in cancer patients are very limited. At the same time, in the absence of adequate supportive treatment of xerosis, the formation of persistent fissures, eczematization and secondary infection is observed, which may lead to antitumor therapy regimen modification. Thus, optimization of prophylactic and treatment strategies for xerosis in patients treated with anticancer drugs remain an important interdisciplinary problem. Balneotherapy is a promising method for the correction of skin xerosis due to a complex positive effect on the level of skin hydration, a decrease in the intensity of inflammatory processes, a beneficial effect on the state of the skin barrier function, as well as an increase in antimicrobial protection. Available data on the use of balneotherapy in the supportive treatment of skin xerosis as a dermatological adverse event of anticancer therapy confirms the high efficacy and safety, as well as good tolerability of this method in cancer patients.
    Type of Medium: Online Resource
    ISSN: 2413-2969 , 1681-3456
    URL: Article
    DOI: 10.17816/rjpbr108026
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Janus kinase inhibitors efficacy for the treatment of adult atopic dermatitis in real clinical practice
    Farmarus Print Media ; 2023
    In:  Russian Journal of Allergy Vol. 20, No. 2 ( 2023-07-09), p. 238-249
    Details
    In: Russian Journal of Allergy, Farmarus Print Media, Vol. 20, No. 2 ( 2023-07-09), p. 238-249
    Abstract: Atopic dermatitis is a common chronic dermatosis characterized by a wide variability of endotypes and phenotypes. Approaches to the treatment of atopic dermatitis are currently undergoing significant changes, especially in patients with moderate and severe forms of atopic dermatitis. JAK inhibitors according to the results of numerous studies have shown their efficacy in the treatment of various immune-mediated dermatological diseases such as atopic dermatitis, vitiligo, focal alopecia and psoriasis, etc. The article presents the experience of treating adult patients suffering from a severe form of atopic dermatitis with the selective JAK-1 inhibitor upadacitinib. The observations presented are of particular interest due to the fact that the patients were treated with upadacitinib monotherapy. It should be noted that the drug is highly effective against itching. No adverse events (including the development of infectious diseases, hematological disorders) were registered during dynamic observation (according to the results of laboratory studies).
    Type of Medium: Online Resource
    ISSN: 2686-682X , 1810-8830
    URL: Issue
    URL: Article
    DOI: 10.36691/RJA.20.2
    DOI: 10.36691/RJA11544
    Language: Unknown
    Publisher: Farmarus Print Media
    Publication Date: 2023
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  • 4
    Online Resource
    Online Resource
    Low-level laser therapy in the supportive treatment of dermatologic adverse events in oncology
    ECO-Vector LLC ; 2022
    In:  Russian Journal of Physiotherapy, Balneology and Rehabilitation Vol. 21, No. 2 ( 2022-12-03), p. 131-141
    Details
    In: Russian Journal of Physiotherapy, Balneology and Rehabilitation, ECO-Vector LLC, Vol. 21, No. 2 ( 2022-12-03), p. 131-141
    Abstract: Supportive treatment plays an important role in oncology nowadays. The main aims of oncologic supportive treatment are management of cancer symptoms and adverse events of cancer treatment. In terms of dermatologic adverse events the most important types of reaction are oral mucositis during radiation therapy, chemotherapy and during hematopoetic stem cell transplantation, palmoplantar syndrome during chemotherapy, palmoplantar skin reaction, acneiform paronychia and pyogenic granulomas during targeted therapy, immune-related dermatologic adverse events during immunotherapy. During recent years, special attention has been paid to low level laser therapy for the prophylaxis and management of cancer therapy dermatologic adverse events. The effects of low level laser therapy may have a beneficial effect on many conditions that play important roles in the pathogenesis of radiation and chemotherapy-induced complications in oncologic patients. Therapeutic effects of low level laser therapy are attributed to the stimulation of adaptive processes and to the increase of nonspecific resistance. The latter develop due to the close interaction of the immune, humoral and nervous systems. When choosing a method for the supportive treatment of cancer therapy adverse events, it is extremely important to establish safety in terms of the tumor process and absence of negative effects on cancer treatment. Effects of low level laser therapy on the proliferative and invasive activity of an existing malignancy remains a matter of debate due to conflicting results from in vitro studies. At the same time, according to the results of numerous clinical studies, the use of this method is assumed to be safe for cancer patients.
    Type of Medium: Online Resource
    ISSN: 2413-2969 , 1681-3456
    URL: Article
    DOI: 10.17816/rjpbr109603
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
    Location Call Number Limitation Availability
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    Online Resource
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