In:
Aging Cell, Wiley, Vol. 22, No. 1 ( 2023-01)
Abstract:
Growth differentiation factor 15 (GDF15) is a stress‐responsive cytokine also known as a mitokine; however, its role in mitochondrial homeostasis and cellular senescence remained elusive. We show here that knocking down GDF15 expression in human dermal fibroblasts induced mitochondrial dysfunction and premature senescence, associated with a distinct senescence‐associated secretory phenotype. Fibroblast‐specific loss of GDF15 expression in a model of 3D reconstructed human skin induced epidermal thinning, a hallmark of skin aging. Our results suggest GDF15 to play a so far undisclosed role in mitochondrial homeostasis to delay both the onset of cellular senescence and the appearance of age‐related changes in a 3D human skin model.
Type of Medium:
Online Resource
ISSN:
1474-9718
,
1474-9726
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2099130-7
SSG:
12
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