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  • 1
    Online Resource
    Online Resource
    Current strategies for adoptive immunotherapy for cancer: ”Off-the-shelf” immune cells
    Biomedical Research and Therapy ; 2020
    In:  Biomedical Research and Therapy Vol. 7, No. 12 ( 2020-12-31), p. 4170-4188
    Details
    In: Biomedical Research and Therapy, Biomedical Research and Therapy, Vol. 7, No. 12 ( 2020-12-31), p. 4170-4188
    Abstract: Immunotherapy, especially immune cell-based therapy, is a strategy for cancer treatment that has over the past decades focused on novel modifications and targets. In recent years, adoptive cell immunotherapy has continuously evolved, with studies of different platforms utilizing different immune effector cells to kill a variety of cancer cells. This review summarizes the various kinds of immune cells which have been used in adoptive cell therapy (ACT), including natural killer cells, cytokine-induced killer cells, T cells, and engineered immune cells. Most reports have shown that ACT can induce tumor regression, both in animal studies and clinical trials. However, the high cost of ACT is the greatest disadvantage of this strategy. Moreover, the efficacy of treatment is variable among patients. To reduce these disadvantages, off-the-shelf immune cells are considered the best solution to reduce the cost while maintaining the efficacy of treatment. In this review, we will discuss the potential of various kinds of immune cells for development as ``off-the-shelf'' immune cells for use in adoptive cell therapy, based on their unique advantages.
    Type of Medium: Online Resource
    ISSN: 2198-4093 , 2198-4093
    URL: Article
    DOI: 10.15419/bmrat.v7i12.655
    Language: Unknown
    Publisher: Biomedical Research and Therapy
    Publication Date: 2020
    detail.hit.zdb_id: 2806789-7
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  • 2
    Online Resource
    Online Resource
    Optimization of culture medium for the isolation and propagation of human breast cancer cells from primary tumour biopsies
    Biomedical Research and Therapy ; 2015
    In:  Biomedical Research and Therapy Vol. 2, No. 2 ( 2015-1)
    Details
    In: Biomedical Research and Therapy, Biomedical Research and Therapy, Vol. 2, No. 2 ( 2015-1)
    Type of Medium: Online Resource
    ISSN: 2198-4093
    URL: Article
    DOI: 10.7603/s40730-015-0006-0
    Language: English
    Publisher: Biomedical Research and Therapy
    Publication Date: 2015
    detail.hit.zdb_id: 2806789-7
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  • 3
    Online Resource
    Online Resource
    Conditioned media from human adipose-derived stem cell culture in some stressed culture conditions differ angiogenic potential
    Biomedical Research and Therapy ; 2021
    In:  Biomedical Research and Therapy Vol. 8, No. 6 ( 2021-06-30), p. 4423-4433
    Details
    In: Biomedical Research and Therapy, Biomedical Research and Therapy, Vol. 8, No. 6 ( 2021-06-30), p. 4423-4433
    Abstract: Introduction: The potency of mesenchymal stem cells (MSCs) related to their biological effects includes immune modulation and angiogenesis. Recently, some stress conditions were applied to enhance the angiogenic potential of MSCs. This study aimed to assess the effects of conditioned media (CM) collected from adipose-derived stem cells’ (ADSCs’) culture under various stress conditions on angiogenesis in vitro. Methods: ADSCs were isolated and expanded according to a published protocol. These cells were treated with some stress conditions including hypoxia, starvation, a combination of hypoxia and starvation, and TNF-alpha treatment. CM from these cultures were collected and used for further experiments. The angiogenic potential of CM was evaluated through stimulation of HUVECs to form vessels in vitro. ELISA was used to measure the VEGF concentrations in CM. Results: CM-derived various stress ADSC cultures differently affected angiogenesis of HUVECs. The supernatant from a hypoxic culture of ADSCs contained the highest concentration of VEGF and was higher than normoxic culture. However, in others, VEGF concentrations in CM significantly reduced compared to control. CM from TNF-alpha treatment failed to support the formation of blood vessels from HUVECs, while other conditions could support blood vessel formation in vitro. TNF-alpha dually affected both ADSCs and HUVECs. Furthermore, TNF-alpha could stimulate or suppress the VEGF production in dose-response in ADSCs and cause apoptosis in HUVECs at high concentrations. Conclusion: CM from the hypoxic culture of ADSCs contained a high concentration of VEGF, supporting angiogenesis of HUVECs well. This is a simple technique that can be used in translational applications. However, the use of TNF-alpha yielded dual effects on ADSCs and HUVECs. Although the VEGF production was enhanced at a low dose of TNF-alpha, they could induce apoptosis in endothelial cells to cause the failure of angiogenesis.  
    Type of Medium: Online Resource
    ISSN: 2198-4093 , 2198-4093
    URL: Article
    DOI: 10.15419/bmrat.v8i6.680
    Language: Unknown
    Publisher: Biomedical Research and Therapy
    Publication Date: 2021
    detail.hit.zdb_id: 2806789-7
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  • 4
    Online Resource
    Online Resource
    Culture and differentiation of cytokine-induced killer cells from umbilical cord blood-derived mononuclear cells
    Biomedical Research and Therapy ; 2016
    In:  Biomedical Research and Therapy Vol. 3, No. 1 ( 2016-2)
    Details
    In: Biomedical Research and Therapy, Biomedical Research and Therapy, Vol. 3, No. 1 ( 2016-2)
    Type of Medium: Online Resource
    ISSN: 2198-4093
    URL: Article
    DOI: 10.7603/s40730-016-0002-z
    Language: English
    Publisher: Biomedical Research and Therapy
    Publication Date: 2016
    detail.hit.zdb_id: 2806789-7
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  • 5
    Online Resource
    Online Resource
    The priming role of dendritic cells on the cancer cytotoxic effects of cytokine-induced killer cells
    Viet Nam National University Ho Chi Minh City ; 2019
    In:  Science and Technology Development Journal Vol. 22, No. 2 ( 2019-05-27), p. 196-212
    Details
    In: Science and Technology Development Journal, Viet Nam National University Ho Chi Minh City, Vol. 22, No. 2 ( 2019-05-27), p. 196-212
    Abstract: Introduction: In vitro cultivation of DCs and cytokine-induced killer cells (CIK cells) - a special phenotype of T lymphocyte populations — for cancer treatment has gained significant research interest. The goal of this study is to understand whether the priming from DCs helps CIK cells to exert their toxic function and kill the cancer cells. Methods: In this research, DCs were differentiated from mononuclear cells in culture medium supplemented with Granulocyte-macrophage colony-stimulating factor (GM-CSF), and Interleukin-4 (IL-4), and were induced to mature with cancer cell antigens. Umbilical cord blood mononuclear cells were induced into CIK cells by Interferon-γ (IFN-γ), anti-CD3 antibody and IL-2. After 4-day exposure (with DC:CIK = 1:10), DCs and CIK cells interacted with each other. Results: Indeed, DCs interacted with and secreted cytokines that stimulated CIK cells to proliferate up to 133.7%. In addition, DC-CIK co-culture also stimulated strong expression of IFN-γ. The analysis of flow cytometry data indicated that DC-CIK co-culture highly expressed Granzyme B (70.47% ± 1.53, 4 times higher than MNCs, twice higher than CIK cells) and CD3+CD56+ markers (13.27% ± 2.73, 13 times higher than MNCs, twice higher than CIK cells). Particularly, DC-CIK co-culture had the most specific lethal effects on cancer cells after 72 hours. Conclusion: In conclusion, co-culture of DCs and CIK cells is capable of increasing the expression of CIK-specific characteristics and CIK toxicity on cancer cells.    
    Type of Medium: Online Resource
    ISSN: 1859-0128 , 1859-0128
    URL: Article
    DOI: 10.32508/stdj.v22i2.1683
    Language: Unknown
    Publisher: Viet Nam National University Ho Chi Minh City
    Publication Date: 2019
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  • 6
    Online Resource
    Online Resource
    Targeting breast cancer stem cells by dendritic cell vaccination in humanized mice with breast tumor: preliminary results
    Informa UK Limited ; 2016
    In:  OncoTargets and Therapy Vol. Volume 9 ( 2016-07), p. 4441-4451
    Details
    In: OncoTargets and Therapy, Informa UK Limited, Vol. Volume 9 ( 2016-07), p. 4441-4451
    Type of Medium: Online Resource
    ISSN: 1178-6930
    URL: Journal
    URL: Article
    DOI: 10.2147/OTT
    DOI: 10.2147/OTT.S105239
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2016
    detail.hit.zdb_id: 2495130-4
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  • 7
    Online Resource
    Online Resource
    Mesenchymal Stem Cells: vector for targeted cancer therapy
    Biomedical Research and Therapy ; 2016
    In:  Progress in Stem Cell Vol. 3, No. 01 ( 2016-03-25), p. 73-
    Details
    In: Progress in Stem Cell, Biomedical Research and Therapy, Vol. 3, No. 01 ( 2016-03-25), p. 73-
    Type of Medium: Online Resource
    ISSN: 2199-4633 , 2199-4633
    URL: Article
    DOI: 10.15419/psc.v3i01.122
    Language: Unknown
    Publisher: Biomedical Research and Therapy
    Publication Date: 2016
    detail.hit.zdb_id: 2884219-4
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  • 8
    Online Resource
    Online Resource
    Synergistic effect of chimeric antigen receptors and cytokine-induced killer cells: An innovative combination for cancer therapy
    Biomedical Research and Therapy ; 2016
    In:  Biomedical Research and Therapy Vol. 3, No. 06 ( 2016-06-26), p. 653-665
    Details
    In: Biomedical Research and Therapy, Biomedical Research and Therapy, Vol. 3, No. 06 ( 2016-06-26), p. 653-665
    Abstract: In recent years, the combination of gene and immunotherapy for cancer treatment has been regarded as innovative and promising; together, both therapies can help overcome limitations associated with conventional treatments. In order to augment anti-cancer efficacy and to maintain the specificity of antibody therapy, chimeric antigen receptor (CAR)-modified T cells, directed toward tumor-specific antigens, have emerged as a novel and promising therapeutic platform. CARs consist of a B cell receptor (BCR)-derived extracellular domain and T cell receptor (TCR)-associated signaling elements. Cytokine-induced killer (CIK) cells are the effector immune cells that can be activated ex vivo and possess both the anti-tumor potency of T lymphocytes and the non-major histocompatibility complex-restricted elimination of natural killer cells. With their pre-eminent ability for robust proliferation, CIK cells may overcome the main limitations of adoptive immunotherapy strategies. CIK cells have strong tumor cell killing capacity; they are effective against a wide variety of malignant tumors and have been shown to be safe in cancer patients. This review summarizes the characteristics of CARs which make them attractive for in cancer treatment strategies. In addition, the role of CIK cells and the advantages of combining CIK cells with CAR-based therapy will be discussed. Scientific evidence to support their combined therapeutic application will be highlighted, with a focus on how their innovative combination may be translated into cancer clinical trials.
    Type of Medium: Online Resource
    ISSN: 2198-4093 , 2198-4093
    URL: Article
    DOI: 10.15419/bmrat.v3i06.99
    Language: Unknown
    Publisher: Biomedical Research and Therapy
    Publication Date: 2016
    detail.hit.zdb_id: 2806789-7
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