In:
Angewandte Chemie, Wiley, Vol. 131, No. 15 ( 2019-04), p. 4945-4949
Abstract:
A general approach for the efficient hydrogen‐isotope exchange of nucleobase derivatives is described. Catalyzed by ruthenium nanoparticles, using mild reaction conditions, and involving either D 2 or T 2 as isotopic sources, this reaction possesses a wide substrate scope and a high solvent tolerability. This novel method facilitates the access to essential diagnostic tools in drug discovery and development: tritiated pharmaceuticals with high specific activities and deuterated oligonucleotides suitable for use as internal standards during LC‐MS quantification.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v131.15
DOI:
10.1002/ange.201813946
Language:
English
Publisher:
Wiley
Publication Date:
2019
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505872-7
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1479266-7
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