In:
Diabetes, American Diabetes Association, Vol. 43, No. 3 ( 1994-03-01), p. 500-504
Abstract:
The role of CD8+ T-cells in the development of diabetes in the nonobese diabetic (NOD) mouse remains controversial. Although it is widely agreed that class II-restricted CD4+ T-cells are essential for the development of diabetes in the NOD model, some studies have suggested that CD8+ T-cells are not required for β-cell destruction. To assess the contribution of CD8+ T-cells to diabetes, we have developed a class of NOD mouse that lacks expression of βxs2-microglobulin (NOD-B2mnull). NOD-B2mnull mice, which lack both class I expression and CD8+ T-cells in the periphery, not only failed to develop diabetes but were completely devoid of insulitis. These results demonstrate an essential role for CD8+ T-cells in the initiation of the autoimmune response to β-cells in the NOD mouse.
Type of Medium:
Online Resource
ISSN:
0012-1797
,
1939-327X
DOI:
10.2337/diab.43.3.500
Language:
English
Publisher:
American Diabetes Association
Publication Date:
1994
detail.hit.zdb_id:
80085-5
detail.hit.zdb_id:
1501252-9
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