In:
Thorax, BMJ, Vol. 73, No. 10 ( 2018-10), p. 980-982
Abstract:
Cilia have multiple functions including olfaction. We hypothesised that olfactory function could be impaired in primary ciliary dyskinesia (PCD). Olfaction, nasal nitric oxide (nNO) and sinus CT were assessed in patients with PCD and non-PCD sinus disease, and healthy controls (no CT scan). PCD and non-PCD patients had similar severity of sinus disease. Despite this, defective olfaction was more common in patients with PCD (P 〈 0.0001) and more severe in patients with PCD with major Transmission Electron Microscopy (TEM) abnormalities. Only in classical PCD did olfaction inversely correlate with sinusitis and nNO. We speculate that defective olfaction in PCD is primary in nature.
Type of Medium:
Online Resource
ISSN:
0040-6376
,
1468-3296
DOI:
10.1136/thoraxjnl-2017-210661
DOI:
10.1136/thoraxjnl-2017-210661.supp1
DOI:
10.1136/thoraxjnl-2017-210661.supp2
DOI:
10.1136/thoraxjnl-2017-210661.supp3
DOI:
10.1136/thoraxjnl-2017-210661.supp4
DOI:
10.1136/thoraxjnl-2017-210661.supp5
DOI:
10.1136/thoraxjnl-2017-210661.supp6
DOI:
10.1136/thoraxjnl-2017-210661.supp7
DOI:
10.1136/thoraxjnl-2017-210661.supp8
DOI:
10.1136/thoraxjnl-2017-210661.supp9
DOI:
10.1136/thoraxjnl-2017-210661.supp10
DOI:
10.1136/thoraxjnl-2017-210661.supp11
DOI:
10.1136/thoraxjnl-2017-210661.supp12
DOI:
10.1136/thoraxjnl-2017-210661.supp13
DOI:
10.1136/thoraxjnl-2017-210661.supp14
DOI:
10.1136/thoraxjnl-2017-210661.supp15
DOI:
10.1136/thoraxjnl-2017-210661.supp16
Language:
English
Publisher:
BMJ
Publication Date:
2018
detail.hit.zdb_id:
1481491-2
Permalink