In:
International Journal of Cancer, Wiley, Vol. 147, No. 1 ( 2020-07), p. 139-151
Abstract:
What's new? Cancer cells fuel their rapid growth by shifting energy metabolism pathways to aerobic glycolysis, thereby enabling accelerated production of ATP, the energy currency of cells. The pyruvate kinase isoform M2 (PKM2) plays a critical role in catalyzing pyruvate and ATP generation in the final step of glycolysis. This study shows that PKM2 is highly expressed in melanoma and that its activity is correlated with melanoma cell invasion and migration. PKM2 activity was successfully inhibited by the decarboxylase inhibitor benserazide, both in vitro and in vivo . In the process of blocking glycolysis, benserazide also facilitated a return to normal energy metabolism.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
Permalink