In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 8 ( 2022-8-30), p. e0263145-
Kurzfassung:
The FDA cleared deep transcranial magnetic stimulation (Deep TMS) with the H7 coil for obsessive-compulsive disorder (OCD) treatment, following a double-blinded placebo-controlled multicenter trial. Two years later the FDA cleared TMS with the D-B80 coil on the basis of substantial equivalence. In order to investigate the induced electric field characteristics of the two coils, these were placed at the treatment position for OCD over the prefrontal cortex of a head phantom, and the field distribution was measured. Additionally, numerical simulations were performed in eight Population Head Model repository models with two sets of conductivity values and three Virtual Population anatomical head models and their homogeneous versions. The H7 was found to induce significantly higher maximal electric fields (p 〈 0.0001, t = 11.08) and to stimulate two to five times larger volumes in the brain (p 〈 0.0001, t = 6.71). The rate of decay of electric field with distance is significantly slower for the H7 coil (p 〈 0.0001, Wilcoxon matched-pairs test). The field at the scalp is 306% of the field at a 3 cm depth with the D-B80, and 155% with the H7 coil. The H7 induces significantly higher intensities in broader volumes within the brain and in specific brain regions known to be implicated in OCD (dorsal anterior cingulate cortex (dACC), dorsolateral prefrontal cortex (dlPFC), inferior frontal gyrus (IFG), orbitofrontal cortex (OFC) and pre-supplementary motor area (pre-SMA)) compared to the D-B80. Significant field ≥ 80 V/m is induced by the H7 (D-B80) in 15% (1%) of the dACC, 78% (29%) of the pre-SMA, 50% (20%) of the dlPFC, 30% (12%) of the OFC and 15% (1%) of the IFG. Considering the substantial differences between the two coils, the clinical efficacy in OCD should be tested and verified separately for each coil.
Materialart:
Online-Ressource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0263145
DOI:
10.1371/journal.pone.0263145.g001
DOI:
10.1371/journal.pone.0263145.g002
DOI:
10.1371/journal.pone.0263145.g003
DOI:
10.1371/journal.pone.0263145.g004
DOI:
10.1371/journal.pone.0263145.g005
DOI:
10.1371/journal.pone.0263145.g006
DOI:
10.1371/journal.pone.0263145.g007
DOI:
10.1371/journal.pone.0263145.t001
DOI:
10.1371/journal.pone.0263145.s001
DOI:
10.1371/journal.pone.0263145.s002
DOI:
10.1371/journal.pone.0263145.s003
DOI:
10.1371/journal.pone.0263145.s004
DOI:
10.1371/journal.pone.0263145.s005
DOI:
10.1371/journal.pone.0263145.s006
DOI:
10.1371/journal.pone.0263145.s007
DOI:
10.1371/journal.pone.0263145.s008
DOI:
10.1371/journal.pone.0263145.s009
DOI:
10.1371/journal.pone.0263145.s010
DOI:
10.1371/journal.pone.0263145.s011
DOI:
10.1371/journal.pone.0263145.s012
Sprache:
Englisch
Verlag:
Public Library of Science (PLoS)
Publikationsdatum:
2022
ZDB Id:
2267670-3
Permalink