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  • 1
    Online Resource
    Online Resource
    Natural Flavonoids as Potential Therapeutics in the Management of Diabetic Wound: A Review
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Topics in Medicinal Chemistry Vol. 23, No. 8 ( 2023-03), p. 690-710
    Details
    In: Current Topics in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 23, No. 8 ( 2023-03), p. 690-710
    Abstract: Flavonoids are important bioactive phenolic compounds abundant in plants and exhibit different therapeutic potentials. A wound is a significant problem in diabetic individuals. A hyper-glycaemic environment alters the normal wound-healing process and increases the risk of microbial infection, leading to hospitalization, morbidity, and amputation. Flavonoids are an important class of phytochemicals with excellent antioxidant, anti-inflammatory, antimicrobial, antidiabetic, anti-tumor, and wound healing property. Quercetin, hesperidin, curcumin, kaempferol, apigenin, luteo-lin, morin, etc. have shown their wound healing potential. Flavonoids effectively exhibit antimicro-bial activity, scavenge reactive oxygen species, augment endogenous antioxidants, reduce the ex-pression and synthesis of inflammatory cytokines (i.e. IL-1β, IL-6, TNF-α, NF-κB), inhibit inflam-matory enzymes, enhance anti-inflammatory cytokine (IL-10), enhance insulin section, reduce insu-lin resistance, and control blood glucose level. Several flavonoids like hesperidin, curcumin, quer-cetin, rutin, naringin, and luteolin have shown their potential in managing diabetic wounds. Natural products that maintain glucose haemostatic, exert anti-inflammatory activity, suppress/inhibit mi-crobial growth, modulate cytokines, inhibit matrix metalloproteinase (MMP), stimulate angiogene-sis and extracellular matrix, and modulate growth factor can be considered as a potential therapeutic lead to treat diabetic wound. Flavonoids were found to play a positive role in management of dia-betic wounds by regulating MMP-2, MMP-8, MMP-9, MMP-13, Ras/Raf/ MEK/ERK, PI3K/Akt, and nitric oxide pathways. Therefore, it can be assumed that flavonoids could be potential therapeu-tics to prevent devastating effects of diabetic wounds. This paper focused on the potential role of flavonoids in managing diabetic wounds and discussed their possible mechanism of action.
    Type of Medium: Online Resource
    ISSN: 1568-0266
    URL: Article
    DOI: 10.2174/1568026623666230419102140
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Therapeutic Repurposing of Antidiabetic Drugs in Diabetes-Associated Comorbidities
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Drug Therapy Vol. 18 ( 2023-05-16)
    Details
    In: Current Drug Therapy, Bentham Science Publishers Ltd., Vol. 18 ( 2023-05-16)
    Abstract: Diabetic patients suffer from various comorbidities like cardiovascular diseases (CVDs), cancer, obesity, cognitive impairment, gout, leishmaniasis, etc. Objective: We aimed to review the pathological links between diabetes and its comorbidities and discuss the justification for using antidiabetic drugs in diabetes and associated comorbidities. Methods: Diabetic patients accompanied by comorbidities had to undergo a multidrug regimen apart from their common antidiabetic drugs, which affects their quality of life. There have been reports that some antidiabetic drugs ameliorate the comorbidities associated with diabetes. For instance, metformin is implicated in CVDs, cancer, as well as in cognitive impairment like Alzheimer's disease (AD); glyburide, a sulfonylurea, is found to be effective against leishmaniasis; and voglibose, an α- glucosidase inhibitor, is found to have suitable binding property against SARS-CoV-2 infection in diabetic patients. Targeting the comorbidities of diabetes with antidiabetic drugs may reduce the load of multidrug therapy in diabetic patients. Result: The effectiveness of antidiabetic drugs against some diabetic comorbidities between the two pathophysiological conditions, i.e., diabetes and its comorbidities, may be due to certain bidirectional links like inflammation, oxidative stress, disruption in the metabolic milieu and obesity. There are published reports of the repurposing of antidiabetic drugs for specific diseases, however, compiled repurposed reports of antidiabetic drugs for a wide range of diseases are scarce. Conclusion: In this review, we attempt to justify the use of antidiabetic drugs in diabetes and associated comorbidities.
    Type of Medium: Online Resource
    ISSN: 1574-8855
    URL: Article
    DOI: 10.2174/1574885518666230516150404
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    Nanotheranostics: application of nanosensors in diabetes management
    Springer Science and Business Media LLC ; 2023
    In:  Journal of Diabetes & Metabolic Disorders Vol. 22, No. 1 ( 2023-03-17), p. 119-133
    Details
    In: Journal of Diabetes & Metabolic Disorders, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2023-03-17), p. 119-133
    Type of Medium: Online Resource
    ISSN: 2251-6581
    URL: Article
    DOI: 10.1007/s40200-023-01206-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2680289-2
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  • 4
    Online Resource
    Online Resource
    Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review
    Elsevier BV ; 2022
    In:  Biomedicine & Pharmacotherapy Vol. 149 ( 2022-05), p. 112901-
    Details
    In: Biomedicine & Pharmacotherapy, Elsevier BV, Vol. 149 ( 2022-05), p. 112901-
    Type of Medium: Online Resource
    ISSN: 0753-3322
    URL: Article
    DOI: 10.1016/j.biopha.2022.112901
    RVK:
    XA 10000
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2022
    detail.hit.zdb_id: 1501510-5
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  • 5
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    Online Resource
    Herbal medicine for the treatment of obesity-associated asthma: a comprehensive review
    Frontiers Media SA ; 2023
    In:  Frontiers in Pharmacology Vol. 14 ( 2023-5-11)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 14 ( 2023-5-11)
    Abstract: Obesity is fast growing as a global pandemic and is associated with numerous comorbidities like cardiovascular disease, hypertension, diabetes, gastroesophageal reflux disease, sleep disorders, nephropathy, neuropathy, as well as asthma . Studies stated that obese asthmatic subjects suffer from an increased risk of asthma, and encounter severe symptoms due to a number of pathophysiology. It is very vital to understand the copious relationship between obesity and asthma, however, a clear and pinpoint pathogenesis underlying the association between obesity and asthma is scarce. There is a plethora of obesity-asthma etiologies reported viz., increased circulating pro-inflammatory adipokines like leptin, resistin, and decreased anti-inflammatory adipokines like adiponectin, depletion of ROS controller Nrf2/HO-1 axis, nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) associated macrophage polarization, hypertrophy of WAT, activation of Notch signaling pathway, and dysregulated melanocortin pathway reported, however, there is a very limited number of reports that interrelates these pathophysiologies. Due to the underlying complex pathophysiologies exaggerated by obese conditions, obese asthmatics respond poorly to anti-asthmatic drugs. The poor response towards anti-asthmatic drugs may be due to the anti-asthmatics approach only that ignores the anti-obesity target. So, aiming only at the conventional anti-asthmatic targets in obese-asthmatics may prove to be futile until and unless treatment is directed towards ameliorating obesity pathogenesis for a holistic approach towards amelioration of obesity-associated asthma. Herbal medicines for obesity as well as obesity-associated comorbidities are fast becoming safer and more effective alternatives to conventional drugs due to their multitargeted approach with fewer adverse effects. Although, herbal medicines are widely used for obesity-associated comorbidities, however, a limited number of herbal medicines have been scientifically validated and reported against obesity-associated asthma. Notable among them are quercetin, curcumin, geraniol, resveratrol, β -Caryophyllene, celastrol, tomatidine to name a few. In view of this, there is a dire need for a comprehensive review that may summarize the role of bioactive phytoconstituents from different sources like plants, marine as well as essential oils in terms of their therapeutic mechanisms. So, this review aims to critically discuss the therapeutic role of herbal medicine in the form of bioactive phytoconstituents against obesity-associated asthma available in the scientific literature to date.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    DOI: 10.3389/fphar.2023.1186060
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 6
    Online Resource
    Online Resource
    Protection by a transdermal patch containing eserine and pralidoxime chloride for prophylaxis against (±)-Anatoxin A poisoning in rats
    Elsevier BV ; 2014
    In:  European Journal of Pharmaceutical Sciences Vol. 56 ( 2014-06), p. 28-36
    Details
    In: European Journal of Pharmaceutical Sciences, Elsevier BV, Vol. 56 ( 2014-06), p. 28-36
    Type of Medium: Online Resource
    ISSN: 0928-0987
    URL: Article
    DOI: 10.1016/j.ejps.2014.01.013
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2014
    detail.hit.zdb_id: 1483522-8
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  • 7
    Online Resource
    Online Resource
    Recent Advances on Natural and Non-Natural Xanthones as Potential Anticancer Agents: A Review
    Bentham Science Publishers Ltd. ; 2023
    In:  Medicinal Chemistry Vol. 19, No. 8 ( 2023-10), p. 757-784
    Details
    In: Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 19, No. 8 ( 2023-10), p. 757-784
    Abstract: Xanthones, natural or synthetic, due to their wide range of biological activities, have become an interesting subject of investigation for many researchers. Xanthonic scaffold has proven to have a vital role in anticancer drug development since many of its derivatives have shown anticancer activities on various cell lines. In addition, targeting epigenetic markers in cancer has yielded promising results. There have also been reports on the impact of xanthone and related polyphenolic compounds on epigenetics markers in cancer prevention and therapy. Objective: The objective of this review is to comprehensively highlight the main natural and nonnatural sources of xanthones having potential anti-cancer effects along with their key structural elements, structure-activity relationships (SARs), mechanisms of action, and epigenetic profile of xanthone- based anti-cancer compounds. The challenges and future directions of xanthone-based therapies are also discussed briefly. Method: The methods involved in the preparation of the present review included the collection of all recent information up to November 2021 from various scientific databases, indexed periodicals, and search engines such as Medline Scopus, Google Scholar, PubMed, PubMed Central, Web of Science, and Science Direct. Results: Exploration of the diversity of the xanthone scaffold led to the identification of several derivatives having prominent anti-cancer activity. Their unique structural diversity and synthetic modifications showed the ongoing endeavour of enriching the chemical diversity of the xanthone molecular framework to discover pharmacologically interesting compounds. However, studies regarding their modes of action, pharmacokinetic properties, clinical data, epigenetics, and safety are limited. Conclusion: Elucidation of the exact biological mechanisms and the associated targets of xanthones will yield better opportunities for these compounds to be developed as potential anticancer drugs. Further clinical studies with conclusive results are required to implement xanthones as treatment modalities in cancer.
    Type of Medium: Online Resource
    ISSN: 1573-4064
    URL: Article
    DOI: 10.2174/1573406419666221226093311
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 8
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    Online Resource
    Design, Synthesis, Computational and Biological Evaluation of Two New Series of 1, 3- and 1,6-dihydroxy Xanthone Derivatives as Selective COX-2 Inhibitors
    Bentham Science Publishers Ltd. ; 2021
    In:  Letters in Drug Design & Discovery Vol. 18, No. 9 ( 2021-11-25), p. 884-914
    Details
    In: Letters in Drug Design & Discovery, Bentham Science Publishers Ltd., Vol. 18, No. 9 ( 2021-11-25), p. 884-914
    Abstract: Over the years, the xanthone nucleus has been serving as an interesting scaffold for the design of derivatives aiming at anti-inflammatory drug development. Objective: The objective of the current work was to design and synthesize two series of novel 3- (5'-substituted pentyloxy)-1-hydroxy xanthone & 6-(5'-substituted pentyloxy)-1-hydroxy xanthone derivatives. The designed compounds were examined in vivo for anti-inflammatory activity. The effect of the synthesized xanthone derivatives on the serum expression of IL-10 and TNF-α was evaluated to understand the underlying molecular mechanisms. Method: The title compounds were virtually designed and screened for ADME/T properties and docked onto the COX-2 protein. The synthesis of the xanthone derivatives was achieved by the condensation of salicylic acid derivatives and a suitable phenol in the presence of a mixture of phosphorus pentoxide–methanesulfonic acid as an acylation catalyst. The compounds were evaluated for in vivo anti-inflammatory activity by carrageenan induced paw edema method and serum expression of cytokines was evaluated using ELISA assays. Results: The selected compounds exhibited docking scores ranging between -10.7 to -6.8 (Kcal/mol), respectively, as compared with standard Celecoxib (-7.9 Kcal/mol) and the nonselective COX inhibitor Indomethacin (-6.4 Kcal/mol). Among the tested compounds, 9u has shown the highest activity with 65.6 % reduction in edema (69.8% for Celecoxib). Immunoassay results showed a significant drop in serum TNF-α and an elevation in serum IL-10. Conclusion: The findings highlight that some of the synthesized xanthone derivatives displayed marked anti-inflammatory activity, which can be further investigated to render efficient and novel non-ulcerogenic anti-inflammatory agents.
    Type of Medium: Online Resource
    ISSN: 1570-1808
    URL: Article
    DOI: 10.2174/1570180818666210427093459
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2021
    SSG: 15,3
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  • 9
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    Online Resource
    Obesity-associated Airway Hyperresponsiveness: Mechanisms Underlying Inflammatory Markers and Possible Pharmacological Interventions
    Bentham Science Publishers Ltd. ; 2023
    In:  Endocrine, Metabolic & Immune Disorders - Drug Targets Vol. 24 ( 2023-11-10)
    Details
    In: Endocrine, Metabolic & Immune Disorders - Drug Targets, Bentham Science Publishers Ltd., Vol. 24 ( 2023-11-10)
    Abstract: Obesity is rapidly becoming a global health problem affecting about 13% of the world’s population affecting women and children the most. Recent studies have stated that obese asthmatic subjects suffer from an increased risk of asthma, encounter severe symptoms, respond poorly to anti-asthmatic drugs, and ultimately their quality-of-life decreases. Although, the association between airway hyperresponsiveness (AHR) and obesity is a growing concern among the public due to lifestyle and environmental etiologies, however, the precise mechanism underlying this association is yet to establish. Apart from aiming at the conventional antiasthmatic targets, treatment should be directed towards ameliorating obesity pathogenesis too. Understanding the pathogenesis underlying the association between obesity and AHR is limited, however, a plethora of obesity pathologies have been reported viz., increased pro-inflammatory and decreased anti-inflammatory adipokines, depletion of ROS controller Nrf2/HO-1 axis, NLRP3 associated macrophage polarization, hypertrophy of WAT, and down-regulation of UCP1 in BAT following down-regulated AMPKα and melanocortin pathway that may be correlated with AHR. Increased waist circumference (WC) or central obesity was thought to be related to severe AHR, however, some recent reports suggest body mass index (BMI), not WC tends to exaggerate airway closure in AHR due to some unknown mechanisms. This review aims to co-relate the above-mentioned mechanisms that may explain the copious relation underlying obesity and AHR with the help of published reports. A proper understanding of these mechanisms discussed in this review will ensure an appropriate treatment plan for patients through advanced pharmacological interventions.
    Type of Medium: Online Resource
    ISSN: 1871-5303
    URL: Article
    DOI: 10.2174/0118715303256440231028072049
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 10
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    Online Resource
    Therapeutic potential of bioactive phytoconstituents found in fruits in the treatment of non-alcoholic fatty liver disease: A comprehensive review
    Elsevier BV ; 2023
    In:  Heliyon Vol. 9, No. 4 ( 2023-04), p. e15347-
    Details
    In: Heliyon, Elsevier BV, Vol. 9, No. 4 ( 2023-04), p. e15347-
    Type of Medium: Online Resource
    ISSN: 2405-8440
    URL: Article
    DOI: 10.1016/j.heliyon.2023.e15347
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2023
    detail.hit.zdb_id: 2835763-2
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