In:
Acta Physiologica, Wiley, Vol. 238, No. 4 ( 2023-08)
Abstract:
We aimed to investigate the inter‐individual variability in redox and physiological responses of antioxidant‐deficient subjects after antioxidant supplementation. Methods Two hundred individuals were sorted by plasma vitamin C levels. A low vitamin C group ( n = 22) and a control group ( n = 22) were compared in terms of oxidative stress and performance. Subsequently, the low vitamin C group received for 30 days vitamin C (1 g) or placebo, in randomized, double‐blind, crossover fashion, and the effects were examined through a mixed‐effects model, while individual responses were calculated. Results The low vitamin C group exhibited lower vitamin C (−25 μmol/L; 95%CI[−31.7, −18.3]; p 〈 0.001), higher F 2 ‐isoprostanes (+17.1 pg/mL; 95%CI[6.5, 27.7]; p = 0.002), impaired VO 2max (−8.2 mL/kg/min; 95%CI[−12.8, −3.6]; p 〈 0.001) and lower isometric peak torque (−41.5 Nm; 95%CI[−61.8, −21.2]; p 〈 0.001) compared to the control group. Regarding antioxidant supplementation, a significant treatment effect was found in vitamin C (+11.6 μmol/L; 95%CI[6.8, 17.1], p 〈 0.001), F 2 ‐isoprostanes (−13.7 pg/mL; 95%CI[−18.9, −8.4], p 〈 0.001), VO 2max (+5.4 mL/kg/min; 95%CI[2.7, 8.2], p = 0.001) and isometric peak torque (+18.7; 95%CI[11.8, 25.7 Nm], p 〈 0.001). The standard deviation for individual responses (SDir) was greater than the smallest worthwhile change (SWC) for all variables indicating meaningful inter‐individual variability. When a minimal clinically important difference (MCID) was set, inter‐individual variability remained for VO 2max , but not for isometric peak torque. Conclusion The proportion of response was generally high after supplementation (82.9%–95.3%); however, a few participants did not benefit from the treatment. This underlines the potential need for personalized nutritional interventions in an exercise physiology context.
Type of Medium:
Online Resource
ISSN:
1748-1708
,
1748-1716
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2219379-0
detail.hit.zdb_id:
2218636-0
SSG:
12
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