In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 4 ( 2021-4-21), p. e0250289-
Abstract:
To describe the patterns of discontinuation and reinitiation in new users of metformin monotherapy in New Zealand, overall and according to person- and healthcare-related factors. Materials and methods We created a cohort (n = 85,066) of all patients in New Zealand with type 2 diabetes mellitus who initiated metformin monotherapy between 1 January 2006 and 30 September 2014 from the national data collections, and followed them until the earlier of their death or 31 December 2015. Discontinuation was defined as a gap in possession of metformin monotherapy of ≥90 days. We explored patterns of discontinuation and reinitiation using competing risks methods. Results After 1 year of follow-up, 28% of cohort members had discontinued metformin monotherapy at least once; the corresponding figures after 2 and 5 years were 37% and 46%. The proportions who reinitiated metformin monotherapy within 1, 2, and 5 years of their first discontinuation were 23%, 49%, and 73%. Discontinuation after the first reinitiation was common (48% after 1 year). Discontinuation and reinitiation varied by age, ethnicity, and other person- and healthcare-related factors. Discussion Our findings highlight the dynamic nature of metformin monotherapy use, show that substantial periods of non-use are common, and identify priority populations for interventions to facilitate adherence.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0250289
DOI:
10.1371/journal.pone.0250289.g001
DOI:
10.1371/journal.pone.0250289.g002
DOI:
10.1371/journal.pone.0250289.t001
DOI:
10.1371/journal.pone.0250289.t002
DOI:
10.1371/journal.pone.0250289.t003
DOI:
10.1371/journal.pone.0250289.s001
DOI:
10.1371/journal.pone.0250289.s002
DOI:
10.1371/journal.pone.0250289.s003
DOI:
10.1371/journal.pone.0250289.s004
DOI:
10.1371/journal.pone.0250289.r001
DOI:
10.1371/journal.pone.0250289.r002
DOI:
10.1371/journal.pone.0250289.r003
DOI:
10.1371/journal.pone.0250289.r004
DOI:
10.1371/journal.pone.0250289.r005
DOI:
10.1371/journal.pone.0250289.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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