In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 116, No. suppl_16 ( 2007-10-16)
Abstract:
Background Assessment of the left ventricular (LV) contractile function is critical for deciding optimal timing of surgery in patients with chronic severe mitral regurgitation (MR). We investigated the LV long-axis and short-axis function in MR. Methods We studied 30 patients (16 men, age: 51 ± 14 years) who had 3+ or 4+ MR with LV ejection fraction (EF) greater than 50%. Comprehensive 2D and Doppler echocardiography was performed. Peak systolic radial (SR R ), circumferential (SR C ), and longitudinal strain rate (SR L ) were measured using speckle tracking imaging. In all patients, peak dP/dt was measured using micromanometer-tipped catheter. Results Mean LVEF was 63.1% and regurgitation fraction was 61.8%. LV end-systolic volume was 78.3 ml. Peak dP/dt ranged from 1019 to 2049 mmHg/sec with the mean value of 1583 mmHg/sec. 16 patients (53.3%) showed latent systolic dysfunction defined by peak dP/dt less than 1300 mmHg/s. SR R and SR C correlated well with peak dP/dt (Fig. A , r=0.74, p 〈 0.01, r=− 0.54, p 〈 0.01, respectively). However, SR L did not correlate with peak dP/dt (r=− 0.58, p=0.76). SR R 〉 1.94 S −1 showed a sensitivity of 86 % and a specificity of 75 % for predicting latent LV systolic function (Fig. B , AUC=0.87, CI=0.732– 0.991). SR R also correlated with LV end-diastolic and end-systolic sphericity index (r=− 0.54, p 〈 0.01, r=− 0.66, p 〈 0.01, respectively). Conclusion SR R and SR C , not SR L , correlated well with peak LV dP/dt. These results imply the importance of short-axis function in the presence of chronic severe MR, probably due to the geometrical change in response to chronic volume overload.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.116.suppl_16.II_763-b
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2007
detail.hit.zdb_id:
1466401-X
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