In:
eLife, eLife Sciences Publications, Ltd, Vol. 6 ( 2017-07-03)
Abstract:
There has been a longstanding debate on whether original fear memory is inhibited or erased after extinction. One possibility that reconciles this uncertainty is that the inhibition and erasure mechanisms are engaged in different phases (early or late) of extinction. In this study, using single-session extinction training and its repetition (multiple-session extinction training), we investigated the inhibition and erasure mechanisms in the prefrontal cortex and amygdala of rats, where neural circuits underlying extinction reside. The inhibition mechanism was prevalent with single-session extinction training but faded when single-session extinction training was repeated. In contrast, the erasure mechanism became prevalent when single-session extinction training was repeated. Moreover, ablating the intercalated neurons of amygdala, which are responsible for maintaining extinction-induced inhibition, was no longer effective in multiple-session extinction training. We propose that the inhibition mechanism operates primarily in the early phase of extinction training, and the erasure mechanism takes over after that.
Type of Medium:
Online Resource
ISSN:
2050-084X
DOI:
10.7554/eLife.25224.001
DOI:
10.7554/eLife.25224.002
DOI:
10.7554/eLife.25224.003
DOI:
10.7554/eLife.25224.004
DOI:
10.7554/eLife.25224.005
DOI:
10.7554/eLife.25224.006
DOI:
10.7554/eLife.25224.007
DOI:
10.7554/eLife.25224.008
DOI:
10.7554/eLife.25224.009
DOI:
10.7554/eLife.25224.010
DOI:
10.7554/eLife.25224.011
DOI:
10.7554/eLife.25224.012
DOI:
10.7554/eLife.25224.013
DOI:
10.7554/eLife.25224.014
DOI:
10.7554/eLife.25224.017
DOI:
10.7554/eLife.25224.018
DOI:
10.7554/eLife.25224.015
DOI:
10.7554/eLife.25224.016
Language:
English
Publisher:
eLife Sciences Publications, Ltd
Publication Date:
2017
detail.hit.zdb_id:
2687154-3
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