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  • Wiley  (11)
  • Park, Hyung Seok  (11)
  • 1
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    Twice‐daily intake of bismuth‐based quadruple therapy for first‐line Helicobacter pylori eradication: A retrospective study on 10‐day, 14‐day, and half‐dose antibiotic therapy
    Wiley ; 2023
    In:  Helicobacter Vol. 28, No. 4 ( 2023-08)
    Details
    In: Helicobacter, Wiley, Vol. 28, No. 4 ( 2023-08)
    Abstract: In areas with 〉 15% clarithromycin resistance, bismuth‐based quadruple therapy is recommended for first‐line Helicobacter pylori eradication. This study aimed to determine the efficacy of the twice‐daily intake of bismuth‐based quadruple therapy among 10‐day, 14‐day, and half‐dose antibiotic regimens. Methods From May 2021 to March 2023, H. pylori ‐infected Korean adults were administered tetracycline (1 g), metronidazole (750 mg), bismuth potassium citrate (300 mg), and lansoprazole (30 mg) twice daily, after breakfast and dinner, for 10 days. The regimen was administered for 14 days if the body weight was ≥70 kg or if the patient had reinfection. Half doses of antibiotics were administered for 14 days if there was a risk of drug interactions or if the patient was aged ≥75 years. The 13 C‐urea breath test was performed after 6 weeks. Results Among the 1258 infected Koreans, 85.1% (412/484) in the 10‐day, 84.3% (498/591) in the 14‐day, and 86.3% (158/183) in the half‐dose antibiotic groups followed the instructions. In the per‐protocol (PP) analysis, eradication rates were higher in the 10‐day (90.5%, p  = 0.019) and 14‐day (90.2%, p  = 0.023) groups than in the half‐dose group (83.5%). In the intention‐to‐treat (ITT) analysis, eradication rates were higher in the 10‐day group (80.6%) than in the half‐dose group (73.2%, p  = 0.039). In the half‐dose group, the eradication rate was lower in patients aged ≥75 years (PP: 74.6%, ITT: 66.2%) than in those with a risk of drug interactions (PP: 89.7% [ p  = 0.017], ITT: 82.4% [ p  = 0.019]). Conclusions Twice‐daily intake of bismuth‐based quadruple therapy for 10–14 days showed an eradication rate of 〉 90% in the PP analysis. A 10‐day regimen could be administered to eradication‐naive patients with a body weight below 70 kg. A half‐dose antibiotic regimen might be recommended to patients with a risk of drug interactions but not to those aged ≥75 years simply due to old age.
    Type of Medium: Online Resource
    ISSN: 1083-4389 , 1523-5378
    URL: Issue
    URL: Article
    DOI: 10.1111/hel.v28.4
    DOI: 10.1111/hel.12998
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020336-6
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  • 2
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    Recurrence of gastroesophageal reflux disease correlated with a short dinner‐to‐bedtime interval
    Wiley ; 2014
    In:  Journal of Gastroenterology and Hepatology Vol. 29, No. 4 ( 2014-04), p. 730-735
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 29, No. 4 ( 2014-04), p. 730-735
    Abstract: Gastroesophageal reflux disease ( GERD ) can be classified into erosive reflux disease ( ERD ) and nonerosive gastroesophageal reflux disease ( NERD ). We aimed to compare the recurrence rates of ERD and NERD and determine the risk factors related to the recurrence. Methods This prospective study comprised 337 consecutive adults who completed questionnaires on their GERD symptoms, height, weight, sleeping position, dinner time, and bedtime. During upper gastrointestinal endoscopy, the presence of a hiatal hernia and mucosal breaks in the low esophagus, esophageal length (the distance between the Z ‐line and the incisors), and the esophageal length‐to‐height ratio were recorded. Recurrence was diagnosed when the patient required additional proton pump inhibitor medication after initial recovery with 4–8 weeks of treatment. Results Recurrence was experienced by 47 (26.0%) of 181 GERD patients. The recurrence rate did not differ between the 48 ERD (27.1%) and 133 NERD (25.6%) patients ( P  = 0.849). Of the various factors studied, recurrence was found to be correlated with a dinner‐to‐bedtime interval of less than 3 h ( P  = 0.002), globus sensation ( P  = 0.031), and old age ( P  = 0.047). Logistic regression analysis revealed that a short interval between dinner and bedtime was the only factor significantly related to the recurrence ( P  = 0.002). Conclusion Both ERD and NERD patients who sleep within 3 h after eating have a higher risk of GERD recurrence. Our findings highlight the impact of a short dinner‐to‐bedtime interval on the recurrence of GERD ( C linical T rials.gov ID : KCT 0000134).
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2014.29.issue-4
    DOI: 10.1111/jgh.12455
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2006782-3
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  • 3
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    Change of mucosal color in early gastric cancer
    Wiley ; 2012
    In:  Journal of Digestive Diseases Vol. 13, No. 10 ( 2012-10), p. 510-516
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 13, No. 10 ( 2012-10), p. 510-516
    Abstract: To investigate the association between mucosal color change and the characteristics of early gastric cancer ( EGC ). Methods:  Data of consecutive patients with EGC resected between August 2005 and October 2010 at K onkuk U niversity M edical C enter were analyzed retrospectively. The characteristics of EGC relative to mucosal color change were analyzed. Results:  Whitish discoloration of the cancer was linked to female to male gender ratio ( P  = 0.009), large tumor size ( P   〈  0.001), deep invasion ( P  = 0.046) and depressed contours ( P   〈  0.001) compared with EGC without discoloration or with hyperemic change. In addition, a whitish discoloration was also related to signet ring cell carcinoma ( P   〈  0.001) and diffuse type carcinoma based on Lauren's classification ( P   〈  0.001). On multiple linear regression analysis, diffuse type based on Lauren's classification ( P  = 0.017) and depth of invasion ( P  = 0.003) were significant independent factors for whitish discoloration. Conclusions:  Mucosal color change is an important clue in the diagnosis of EGC . EGC with whitish discoloration needs more attention due to its link with the diffuse type of Lauren's classification.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.2012.13.issue-10
    DOI: 10.1111/j.1751-2980.2012.00620.x
    Language: English
    Publisher: Wiley
    Publication Date: 2012
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  • 4
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    Combining the serum pepsinogen level and H elicobacter pylori antibody test for predicting the histology of gastric neoplasm
    Wiley ; 2014
    In:  Journal of Digestive Diseases Vol. 15, No. 6 ( 2014-06), p. 293-298
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 15, No. 6 ( 2014-06), p. 293-298
    Abstract: To determine whether the combination test of serum pepsinogen ( PG ) levels and H elicobacter pylori ( H. pylori ) antibody was effective for predicting the incidence and histology of gastric neoplasms. Methods This study included asymptomatic K orean adults who underwent esophagogastroduodenoscopy with blood tests for PG levels and H . pylori immunoglobulin G antibody test on the same day. Participants with extragastric malignancy, history of H . pylori eradication or gastric neoplasms, or recent antacid medication were excluded. Gastric atrophy was defined as a serum PG I/II ratio ≤3.0 and PG I ≤70 ng/mL. The participants were classified into four groups according to the presence (+) or absence (−) of gastric atrophy and H . pylori infection. Results Of the 3328 included participants, 17 were incidentally diagnosed as having either gastric adenoma or carcinoma. The incidence of gastric neoplasm was highest in the gastric atrophy (+)/H. pylori (−) group (4.17%; OR 25.8, P  = 0.009), but the neoplasm exhibited the least advanced histology. The gastric atrophy (−)/H. pylori (−) group exhibited the lowest incidence of gastric neoplasm (0.17%) but the most advanced histology. Conclusion A combination of serum PG levels and H . pylori antibody test is useful for detecting gastric neoplasms based on the slow gastric carcinogenesis pathway progressing from gastric adenoma to L auren's intestinal‐type gastric cancer, but not for those with advanced histology such as L auren's diffuse‐type gastric cancer.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.2014.15.issue-6
    DOI: 10.1111/1751-2980.12144
    Language: English
    Publisher: Wiley
    Publication Date: 2014
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  • 5
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    Efficacy and safety of flumazenil injection for the reversal of midazolam sedation after elective outpatient endoscopy
    Wiley ; 2018
    In:  Journal of Digestive Diseases Vol. 19, No. 2 ( 2018-02), p. 93-101
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 19, No. 2 ( 2018-02), p. 93-101
    Abstract: Midazolam sedation during elective endoscopy is widely performed and flumazenil is frequently administered after endoscopy to reverse sedation in clinical practice. This study aimed to investigate the safety and efficacy of flumazenil injections after elective endoscopy under midazolam sedation. METHODS Participants who underwent an upper endoscopy under midazolam sedation were randomly divided into two groups. In group I, flumazenil was administered i.v. 10 min after the patient's transfer to the recovery room, and no antidote was injected in group II. The time of stay in the recovery room and adverse events were reviewed through the nursing records. We asked the patients about their pain and degree of satisfaction according to a visual analogue scale (VAS), their memory of the procedure, mental status and the presence of uncomfortable symptoms on the day of the procedure and the day afterwards. RESULTS The length of stay in recovery was significantly shorter in group I than in group II. No significant differences were found in the number of patients with pain (VAS ≥1), adverse events and discomfort between the two groups. Additionally, there were no differences in the patients’ memory of the procedure, satisfaction with sedation, willingness to repeat the endoscopy and mental status. CONCLUSIONS The time in the recovery room after flumazenil administration was significantly shortened, and the use of the drug did not increase the risk of adverse events or discomfort. The use of flumazenil for reversing midazolam sedation seems to be safe and effective.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.2018.19.issue-2
    DOI: 10.1111/1751-2980.12579
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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  • 6
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    Comparison of dexmedetomidine with on‐demand midazolam versus midazolam alone for procedural sedation during endoscopic submucosal dissection of gastric tumor
    Wiley ; 2015
    In:  Journal of Digestive Diseases Vol. 16, No. 7 ( 2015-07), p. 377-384
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 16, No. 7 ( 2015-07), p. 377-384
    Abstract: Endoscopic submucosal dissection ( ESD ) is commonly performed as a treatment for gastric neoplasms. However, sedation with midazolam ( MDZ ) often does not reach satisfactory sedation levels during the procedure and the drug may suppress respiration and blood pressure. This study aimed to investigate the safety and efficacy of dexmedetomidine ( DEX ) with on‐demand MDZ (the DEX group) in comparison with MDZ alone (the MDZ group) as a sedative during ESD of gastric neoplasms. Methods Eighty patients undergoing ESD for gastric tumor were randomly assigned to one of two treatment regimens (40 patients in each). We investigated the depth of sedation by using a Modified Observers Assessment Alertness/Sedation score, the number of patients' reactions interfering with the procedure, sedation related‐adverse events and the degree of satisfaction of patients and doctors. Results There was no statistically significant difference between the two groups regarding their age, gender, body mass index, American Society of Anesthesiologists physical status classification and the characteristics of the tumor. Appropriate sedation rate and the degree of satisfaction of the doctors were significantly higher in the DEX group than in the MDZ group. Patients' reactions interfering with the procedure were more numerous in the MDZ group than in the DEX group. There was no significant difference in adverse events between the two groups. Conclusions DEX with on‐demand MDZ for sedation during gastric ESD is as safe as MDZ alone and the sedation effect of DEX with MDZ is superior to that of MDZ alone.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.2015.16.issue-7
    DOI: 10.1111/1751-2980.12254
    Language: English
    Publisher: Wiley
    Publication Date: 2015
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  • 7
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    Effect of submucosal fibrosis on endoscopic submucosal dissection of colorectal tumors: Pathologic review of 173 cases
    Wiley ; 2015
    In:  Journal of Gastroenterology and Hepatology Vol. 30, No. 5 ( 2015-05), p. 872-878
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 30, No. 5 ( 2015-05), p. 872-878
    Abstract: Endoscopic submucosal dissection ( ESD ) is now commonly performed as a treatment for colorectal tumors. However, little is known about the relationship between submucosal fibrosis and the outcome of the colonic ESD procedure. The aims of this study were to investigate the relationship between the degree of submucosal fibrosis in colorectal tumors and the outcomes of ESD for these tumors and to evaluate the risk factors for submucosal fibrosis. Methods We retrospectively reviewed the records of patients with colorectal adenoma or carcinoma who had undergone an ESD , during a four‐year period from J anuary 2010 to D ecember 2013. The resected specimens were histologically examined after M asson's trichrome staining, and the severity of the submucosal fibrosis was classified as no fibrosis ( F0 ), mild fibrosis ( F1 ), or severe fibrosis ( F2 ). Results Among a total of 173 cases (106 male, mean age 65.0 ± 10.2 years; F0 33, F1 78, F2 62) enrolled, 46 incidences of complications (perforation 19, post‐coagulation syndrome 21, bleeding 6) had developed. Multivariate analysis revealed that F2 fibrosis was significantly associated with the development of complications. Submucosal invasion and large tumor size (≥ 30 mm) were identified as independent predictors of F2 fibrosis. Conclusion Severe fibrosis is the most powerful risk factor for complications and can interfere with en bloc resections. The possibility of submucosal fibrosis should be considered, and the procedure should be cautiously performed in cases where the tumor diameter is greater than 30 mm and when submucosal cancer is suspected.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2015.30.issue-5
    DOI: 10.1111/jgh.12886
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2006782-3
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  • 8
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    Correlation Between H elicobacter pylori Infection, I g E Hypersensitivity, and Allergic Disease in K orean Adults
    Wiley ; 2015
    In:  Helicobacter Vol. 20, No. 1 ( 2015-02), p. 49-55
    Details
    In: Helicobacter, Wiley, Vol. 20, No. 1 ( 2015-02), p. 49-55
    Abstract: The correlation between allergic disease and H elicobacter pylori infection is still controversial in endemic areas. The aim of this study was to determine whether H . pylori infection is related to allergic disease and/or immunoglobulin E ( I g E ) hypersensitivity in K orean adults. Materials and Methods Consecutive K orean adults who visited our center for a routine checkup were enrolled. All subjects completed a questionnaire that was designed to ascertain their medical history pertaining to physician‐diagnosed allergic disease, allergy treatments, and H . pylori eradication therapy. Blood was sampled for serum anti‐ H . pylori I g G antibody. I g E hypersensitivity was measured using a commercially available I mmuno CAP ® P hadiatop ( P hadia AB , U ppsala, S weden). Results Of the 3376 K orean adults who were enrolled, 62 did not answer to the questionnaires adequately and were thus excluded. The proportion of noninfected subjects ( p  〈   .001) and the prevalence of I g E ‐related allergic disease ( p  〈   .001) were both highest among those aged 〈 40 years, while the prevalence of non‐ I g E ‐related allergic disease was highest among those aged ≥70 years ( p  〈   .001). Logistic regression analysis revealed that being younger than 40 years was significantly related to the absence of H . pylori infection ( OR  = 2.507, 95% CI  = 1.621–3.878, p  〈   .001). Conclusions The statuses of H . pylori infection, I g E hypersensitivity, and allergic diseases differ with age group, there being a higher prevalence of I g E ‐related allergic disease and a lower H . pylori infection rate among young adults. The hygiene hypothesis might explain these findings in young K oreans, due to the rapid development and improvements in sanitation in K orea.
    Type of Medium: Online Resource
    ISSN: 1083-4389 , 1523-5378
    URL: Issue
    URL: Article
    DOI: 10.1111/hel.2014.20.issue-1
    DOI: 10.1111/hel.12173
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2020336-6
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  • 9
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    The histologic detection of Helicobacter pylori in seropositive subjects is affected by pathology and secretory ability of the stomach
    Wiley ; 2018
    In:  Helicobacter Vol. 23, No. 3 ( 2018-06)
    Details
    In: Helicobacter, Wiley, Vol. 23, No. 3 ( 2018-06)
    Abstract: Helicobacter pylori is unevenly distributed in hypochlorhydric environments. The study aim was to elucidate the risk factors for a negative Giemsa staining finding in seropositive subjects by measuring the secretory ability of the stomach. Methods Subjects aged over 18 years were included consecutively after endoscopic biopsy at gastric lesions with color or structural changes. Blood was sampled for the serum pepsinogen ( PG ) assay and H. pylori serology test. After excluding the subjects with past H. pylori eradication, the risk factors for a negative Giemsa staining finding in seropositive subjects were analyzed. Results Among 872 included subjects, a discrepancy between the serum anti‐ H. pylori IgG and Giemsa staining findings was found in 158 (18.1%) subjects, including 145 Giemsa‐negative, seropositive subjects. Gastric adenocarcinoma/adenoma ( OR  = 11.090, 95% CI  = 3.490‐35.236) and low serum PG II level ( OR  = 0.931, 95% CI  = 0.899‐0.963) were the independent risk factors for a negative Giemsa staining finding in seropositive subjects. The cutoff value of serum PG II level was 7.45 ng/ mL (area under curve [ AUC ] = 0.904, 95% CI  = 0.881‐0.927). Follow‐up studies of Giemsa staining at different sites of the stomach revealed that 75% of the Giemsa‐negative seropositive subjects with adenocarcinoma are positive, whereas none of those with low serum PG II level of 〈 7.45 ng/ mL revealed positive findings. Conclusions The risk of a negative Giemsa staining finding in seropositive subjects is increased in gastric adenocarcinoma/adenoma specimens and in subjects with a diminished gastric secretory ability with low serum PG II level of 〈 7.45 ng/ mL . A false‐negative Giemsa staining finding is common in subjects with adenocarcinoma, and therefore, additional biopsies at different sites should be performed in these subjects.
    Type of Medium: Online Resource
    ISSN: 1083-4389 , 1523-5378
    URL: Issue
    URL: Article
    DOI: 10.1111/hel.2018.23.issue-3
    DOI: 10.1111/hel.12480
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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  • 10
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    Efficacy and safety of twice a day, bismuth‐containing quadruple therapy using high‐dose tetracycline and metronidazole for second‐line Helicobacter pylori eradication
    Wiley ; 2020
    In:  Helicobacter Vol. 25, No. 2 ( 2020-04)
    Details
    In: Helicobacter, Wiley, Vol. 25, No. 2 ( 2020-04)
    Abstract: Conventional second‐line, bismuth‐containing quadruple therapy is administered four times a day. We aimed to evaluate the efficacy and safety of twice a day administration compared to the four times a day therapy. Methods Medical records of consecutive patients with positive 13 C‐urea breath tests (UBTs) after first‐line eradication were reviewed. From December 2018 to June 2019, 100 consecutive 13 C‐UBT‐positive patients received tetracycline 1 g, metronidazole 750 mg, bismuth subcitrate 300 mg, and pantoprazole 20 mg twice a day for one week. The same number of consecutive 13 C‐UBT‐positive patients before December 2018 was included as controls. The control group received tetracycline 500 mg and bismuth subcitrate 300 mg four times a day, metronidazole 500 mg three times a day, and pantoprazole 20 mg twice a day for one week. Eradication was confirmed based on a 13 C‐UBT performed in the 5th week after taking quadruple therapy. Results Ninety‐eight patients from the twice a day group and 99 patients from the four times a day group were analyzed. The eradication rate did not differ between the twice a day group (92/98, 93.9%) and the four times a day group (92/99, 92.9%). Adverse drug effects were found in 36 patients from the twice a day group and 50 patients from the four times a day group ( P  = .051). Abdominal pain, discomfort, and distention were more common with four times a day intake (13.1%) than with twice a day intake (4.1%; P  = .024). Conclusions We determined for the first time that twice a day intake of bismuth‐containing quadruple therapy using 2 g/d of tetracycline, 1.5 g/d of metronidazole, and 600 mg/d of bismuth subcitrate for one week is effective and safe as the conventional four times a day therapy. Twice a day intake decreased abdominal pain, discomfort, and distention.
    Type of Medium: Online Resource
    ISSN: 1083-4389 , 1523-5378
    URL: Issue
    URL: Article
    DOI: 10.1111/hel.v25.2
    DOI: 10.1111/hel.12683
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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