In:
Tumori Journal, SAGE Publications, Vol. 68, No. 6 ( 1982-12), p. 515-518
Abstract:
Eighteen evaluable patients with advanced malignant lymphoma were treated with a combination of cis-dichlorodiammineplatinum (II) (50 mg/m 2 i.v. on day 1), VP 16-213 (100 mg/m 2 i.v. on days 1, 3, 5), and prednisone (50 mg/m 2 per os on days 1–5), recycling every 2 weeks. All patients were previously pretreated. There were 3 complete remissions (patients with Hodgkin's disease), and 4 partial remission (2 patients with Hodgkin's and 2 with non-Hodgkin's lymphoma), for a median duration of 8 weeks. In addition, 2 minor responses (patients with Hodgkin's disease) were observed. Vomiting and myelosuppression were the most prominent toxic effects. In most heavily pretreated patients, myelosuppression was moderate to severe: in these patients and in patients with bone marrow involvement, a schedule interval of 3 weeks should be more appropriate. Nephrotoxicity was minimal. This combination chemotherapy showed some activity in the management of advanced malignant lymphomas; further studies in this area are justified.
Type of Medium:
Online Resource
ISSN:
0300-8916
,
2038-2529
DOI:
10.1177/030089168206800611
Language:
English
Publisher:
SAGE Publications
Publication Date:
1982
detail.hit.zdb_id:
280962-X
detail.hit.zdb_id:
2267832-3
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