In:
Annals of Human Genetics, Wiley, Vol. 70, No. 6 ( 2006-11), p. 749-758
Abstract:
In our research we examined the contribution of putative genetic sources on interindividual variation and cross‐sectional correlations of several adhesion molecules, including intracellular (ICAM‐1) and vascular cell adhesion molecules (VCAM‐1) and E‐selectin, in a population‐based sample of ethnically homogeneous families of European origin. The plasma levels of these molecules were measured in 947 apparently healthy individuals from 217 nuclear families. Quantitative statistical‐genetic analysis implementing the model fitting technique revealed significant parent/offspring and sibling correlations (p 〈 0.01) for all three molecules. The putative genetic effects explained 55.2 ± 7.2% (VCAM‐1), 63.3 ± 7.5% (ICAM) and 63.8 ± 8.1% (E‐selectin) of the variation. Common family environmental factors also significantly influenced the variation of E‐selectin (13%) and VCAM‐1 (28.6%). The main results of our bivariate analysis showed that the observed phenotypic correlations between ICAM‐1 and VCAM‐1, and between ICAM‐1 and E‐selectin, were mostly attributable to shared environmental factors ( r E = 0.896 and 0.737, respectively; p 〈 0.01). However, the correlation between VCAM‐1 and E‐selectin was likely caused by common genetic effects (r G = 0.334, p 〈 0.05) . Our results show that familial clustering of adhesion molecules is likely due to strong genetic effects, supplemented with shared environmental factors.
Type of Medium:
Online Resource
ISSN:
0003-4800
,
1469-1809
DOI:
10.1111/ahg.2006.70.issue-6
DOI:
10.1111/j.1469-1809.2006.00275.x
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
1470206-X
SSG:
12
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