In:
VIEW, Wiley
Abstract:
Early diagnosis of gastrointestinal malignancies in patients with acute coronary syndrome (ACS) is often delayed. The present study aims to demonstrate the value of [ 68 Ga]Ga‐FAPI‐04 PET imaging in ACS with suspected gastrointestinal malignancies. Twelve ACS patients with suspected gastrointestinal malignancies were enrolled, including ST‐elevation myocardial infarction (STEMI) ( n = 5), non‐ST‐elevation myocardial infarction (NSTEMI) ( n = 5), and unstable angina (UA) ( n = 2). All patients underwent coronary angiography (CAG) and [ 68 Ga]Ga‐FAPI‐04 PET/MR o r PET/CT within 1 week. All five STEMI and five NSTEMI patients had high [ 68 Ga]Ga‐FAPI‐04 uptake in the injured myocardium compared to remote area (TBR: 2.10 ± 0.72 vs. 0.62 ± 013; p 〈 .001), correlated with peak cTnI level ( R = .82, p = .004). No [ 68 Ga]Ga‐FAPI‐04 in the myocardium was found in UA patients. NSTEMI displayed a similar myocardial [ 68 Ga]Ga‐FAPI‐04 intensity as STEMI ( p = .42). Compared with STEMI, NSTEMI patients had a significantly delayed door‐to‐balloon time for reperfusion treatment ( p = .023). High uptake of [ 68 Ga]Ga‐FAPI‐04 in the gastrointestinal tract was detected in three patients. Because of no myocardial [ 68 Ga]Ga‐FAPI‐04 expression, they discontinued antiplatelet therapy and underwent endoscopy. The rectal, colon, and gastric cancer diagnoses were made by biopsy. The other nine patients showed no accumulation of [ 68 Ga]Ga‐FAPI‐04 beyond the heart, and invasive tumor examinations were delayed. During a median 6‐month follow‐up, no tumor formation was observed. [ 68 Ga]Ga‐FAPI‐04 PET imaging is valuable to assess injured myocardium, detect tumors, and guide invasive examinations in ACS patients with suspected gastrointestinal malignancies.
Type of Medium:
Online Resource
ISSN:
2688-268X
,
2688-268X
DOI:
10.1002/VIW.20230018
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
3021474-9
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