In:
Acta Obstetricia et Gynecologica Scandinavica, Wiley, Vol. 95, No. 8 ( 2016-08), p. 926-933
Kurzfassung:
The aim of this study was to evaluate, in women with preterm prelabor rupture of membranes ( PPROM ), the impact on short‐term neonatal outcome of microbial invasion of the amniotic cavity ( MIAC ), intra‐amniotic inflammation ( IAI ), and the microorganisms isolated in women with MIAC , when gestational age is taken into account. Material and methods Prospective cohort study. We included women with PPROM (22.0–34.0 weeks of gestation) with available information about MIAC , IAI and short‐term neonatal outcome. MIAC was defined as positive aerobic/anaerobic/genital Mycoplasma culture in amniotic fluid. Definition of IAI was based on interleukin‐6 levels in amniotic fluid. Main outcome measures were Apgar score 〈 7 at 5 min, umbilical artery pH ≤7.0, days in the neonatal intensive care unit, and composite neonatal morbidity, including any of the following: intraventricular hemorrhage grade III – IV , respiratory distress syndrome, early‐onset neonatal sepsis, periventricular leukomalacia, necrotizing enterocolitis, and fetal or neonatal death. Labor was induced after 32.0 weeks if lung maturity was confirmed; and otherwise after 34.0 weeks. Results MIAC and IAI were found in 38% (72/190) and 67% (111/165), respectively. After adjustment for gestational age at delivery, no differences in short‐term neonatal outcome were found between women with either MIAC or IAI , compared with the non‐infection/non‐inflammation (“No‐ MIAC /No‐ IAI ”) group. Furthermore, short‐term neonatal outcome did not differ between the MIAC caused by Ureaplasma spp. group, the MIAC caused by other microorganisms group and the “No‐ MIAC /No‐ IAI ” group. Conclusions Gestational age at delivery seems to be more important for short‐term neonatal outcome than MIAC or IAI in PPROM .
Materialart:
Online-Ressource
ISSN:
0001-6349
,
1600-0412
DOI:
10.1111/aogs.2016.95.issue-8
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2016
ZDB Id:
2024554-3
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