In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 5 ( 2021-5-7), p. e0251236-
Abstract:
The advent of affordable, portable ultrasound devices has led to increasing interest in the use of point-of-care ultrasound (POCUS) for the detection of pulmonary TB (PTB). We undertook a systematic review of the diagnostic accuracy of POCUS for PTB. Five databases were searched for articles published between January 2010 and June 2020. Risk of bias was assessed using QUADAS-2. Data on sensitivity and specificity of individual lung ultrasound findings were collected, with variable reference standards including PCR and sputum smear microscopy. Six of 3,919 reviewed articles were included: five in adults and one in children, with a total sample size of 564. Studies had high risk of bias in many domains. In adults, subpleural nodule and lung consolidation were the lung ultrasound findings with the highest sensitivities, ranging from 72.5% to 100.0% and 46.7% to 80.4%, respectively. Only one study reported specificity data. Variability in sensitivity may be due to variable reference standards or may imply operator dependence. There is insufficient evidence to judge the diagnostic accuracy of POCUS for PTB. There is also no consensus on the optimal protocols for acquiring and analysing POCUS images for PTB. New studies which minimise potential sources of bias are required to further assess the diagnostic accuracy of POCUS for PTB.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0251236
DOI:
10.1371/journal.pone.0251236.g001
DOI:
10.1371/journal.pone.0251236.g002
DOI:
10.1371/journal.pone.0251236.t001
DOI:
10.1371/journal.pone.0251236.t002
DOI:
10.1371/journal.pone.0251236.t003
DOI:
10.1371/journal.pone.0251236.t004
DOI:
10.1371/journal.pone.0251236.t005
DOI:
10.1371/journal.pone.0251236.t006
DOI:
10.1371/journal.pone.0251236.t007
DOI:
10.1371/journal.pone.0251236.t008
DOI:
10.1371/journal.pone.0251236.s001
DOI:
10.1371/journal.pone.0251236.s002
DOI:
10.1371/journal.pone.0251236.s003
DOI:
10.1371/journal.pone.0251236.s004
DOI:
10.1371/journal.pone.0251236.s005
DOI:
10.1371/journal.pone.0251236.s006
DOI:
10.1371/journal.pone.0251236.s007
DOI:
10.1371/journal.pone.0251236.r001
DOI:
10.1371/journal.pone.0251236.r002
DOI:
10.1371/journal.pone.0251236.r003
DOI:
10.1371/journal.pone.0251236.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
Permalink