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  • Wiley  (2)
  • Pacchiarotti, Isabella  (2)
  • 1
    Online Resource
    Online Resource
    The role of different patterns of psychomotor symptoms in major depressive episode: Pooled analysis of the BRIDGE and BRIDGE‐II‐MIX cohorts
    Wiley ; 2019
    In:  Bipolar Disorders Vol. 21, No. 8 ( 2019-12), p. 785-793
    Details
    In: Bipolar Disorders, Wiley, Vol. 21, No. 8 ( 2019-12), p. 785-793
    Abstract: Psychomotor agitation (PA) or retardation (PR) during major depressive episodes (MDEs) have been associated with depression severity in terms of treatment‐resistance and course of illness. Objectives We investigated the possible association of psychomotor symptoms (PMSs) during a MDE with clinical features belonging to the bipolar spectrum. Methods The initial sample of 7689 MDE patients was divided into three subgroups based on the presence of PR, PA and non‐psychomotor symptom (NPS). Univariate comparisons and multivariate logistic regression models were performed between subgroups. Results A total of 3720 patients presented PR (48%), 1971 showed PA (26%) and 1998 had NPS (26%). In the PR and PA subgroups, the clinical characteristics related to bipolarity, along with the diagnosis of bipolar disorder (BD), were significantly more frequent than in the NPS subgroup. When comparing PA and PR patients, the former presented higher rates of bipolar spectrum features, such as family history of BD (OR = 1.39, CI = 1.20‐1.61), manic/hypomanic switches with antidepressants (OR = 1.28, CI = 1.11‐1.48), early onset of first MDE (OR = 1.40, CI = 1.26‐1.57), atypical (OR = 1.23, CI = 1.07‐1.42) and psychotic features (OR = 2.08, CI = 1.78‐2.44), treatment with mood‐stabilizers (OR = 1.39, CI = 1.24‐1.55), as well as a BD diagnosis according to both the DSM‐IV criteria and the bipolar specifier criteria. When logistic regression model was performed, the clinical features that significantly differentiated PA from PR were early onset of first MDE, atypical and psychotic features, treatment with mood‐stabilizers and a BD diagnosis according to the bipolar specifier criteria. Conclusions Psychomotor symptoms could be considered as markers of bipolarity, illness severity, and treatment complexity, particularly if PA is present.
    Type of Medium: Online Resource
    ISSN: 1398-5647 , 1399-5618
    URL: Issue
    URL: Article
    DOI: 10.1111/bdi.v21.8
    DOI: 10.1111/bdi.12816
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2001157-X
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  • 2
    Online Resource
    Online Resource
    Obesity in patients with major depression is related to bipolarity and mixed features: evidence from the BRIDGE ‐ II ‐ Mix study
    Wiley ; 2017
    In:  Bipolar Disorders Vol. 19, No. 6 ( 2017-09), p. 458-464
    Details
    In: Bipolar Disorders, Wiley, Vol. 19, No. 6 ( 2017-09), p. 458-464
    Abstract: The Bipolar Disorders: Improving Diagnosis, Guidance and Education (BRIDGE) ‐ II ‐ Mix study aimed to estimate the frequency of mixed states in patients with a major depressive episode (MDE) according to different definitions. The present post‐hoc analysis evaluated the association between obesity and the presence of mixed features and bipolarity. Methods A total of 2811 MDE subjects were enrolled in a multicenter cross‐sectional study. In 2744 patients, the body mass index ( BMI ) was evaluated. Psychiatric symptoms, and sociodemographic and clinical variables were collected, comparing the characteristics of MDE patients with ( MDE ‐ OB ) and without ( MDE ‐ NOB ) obesity. Results Obesity ( BMI ≥30) was registered in 493 patients (18%). In the MDE ‐ OB group, 90 patients (20%) fulfilled the DSM ‐ IV ‐ TR criteria for bipolar disease (BD) , 225 patients (50%) fulfilled the bipolarity specifier criteria, 59 patients (13%) fulfilled DSM ‐5 criteria for MDEs with mixed features, and 226 patients (50%) fulfilled Research‐Based Diagnostic Criteria for an MDE. Older age, history of (hypo)manic switches during antidepressant treatment, the occurrence of three or more MDE s, atypical depressive features, antipsychotic treatment, female gender, depressive mixed state according to DSM ‐5 criteria, comorbid eating disorders, and anxiety disorders were significantly associated with the MDE ‐ OB group. Among (hypo)manic symptoms during the current MDE , psychomotor agitation, distractibility, increased energy, and risky behaviors were the variables most frequently associated with MDE ‐ OB group. Conclusions In our sample, the presence of obesity in patients with an MDE seemed to be associated with higher rates of bipolar spectrum disorders. These findings suggest that obesity in patients with an MDE could be considered as a possible marker of bipolarity.
    Type of Medium: Online Resource
    ISSN: 1398-5647 , 1399-5618
    URL: Issue
    URL: Article
    DOI: 10.1111/bdi.2017.19.issue-6
    DOI: 10.1111/bdi.12519
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2001157-X
    Location Call Number Limitation Availability
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