In:
Journal of Arrhythmia, Wiley, Vol. 31, No. 5 ( 2015-10), p. 302-306
Abstract:
Approximately one‐third of the patients undergoing cardiovascular surgery reportedly experience paroxysmal atrial fibrillation (AF) during the postoperative period. However, the usefulness of antiarrhythmic drugs for preventing postoperative AF recurrence in the Japanese population has not been extensively studied. Methods From a total of 118 patients who developed postoperative paroxysmal AF between April 2009 and March 2011, 72 patients (45 men, mean age 68±8 years) requiring treatment for postoperative AF due to symptoms lasting ≥30 min were enrolled to prospectively investigate the efficacy of oral bepridil (100 mg/day, n =37) or aprindine (40 mg/day, n =35). Result The AF recurrence‐free survival rates at 1, 3, 7, and 14 days were 100%, 94%, 57%, and 49%, respectively, in the aprindine group, and 100%, 97%, 86%, and 76%, respectively, in the bepridil group ( P =0.028, aprindine vs. bepridil). Conclusion Bepridil, at a fixed dose of 100 mg/day, was considered to be more effective than a routine dose of aprindine for the prevention of postoperative AF recurrence.
Type of Medium:
Online Resource
ISSN:
1880-4276
,
1883-2148
DOI:
10.1016/j.joa.2015.04.003
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
2696593-8
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