In:
Catheterization and Cardiovascular Interventions, Wiley, Vol. 98, No. 5 ( 2021-11)
Abstract:
To investigate whether hemodynamic changes during balloon occlusion test (BOT) predict future heart failure (HF) deterioration after transcatheter atrial septal defect closure (tASD‐closure). Background Midterm HF deterioration can sometimes occur after tASD‐closure in adults. Whether hemodynamic changes during tASD‐closure can help identify patients at risk is unknown. Methods This prospective observational study enrolled 86 consecutive adult patients who underwent tASD‐closure. Hemodynamic parameters, including pulmonary capillary wedge pressure (PCWP), were measured at baseline, during BOT, and after tASD‐closure. The changes in PCWP during BOT and after tASD‐closure were defined as ΔPCWP (Occ‐Pre) and ΔPCWP (Post‐Pre), respectively. Clinical parameters were evaluated before tASD‐closure and during the 3‐month follow‐up. We assessed the occurrence of HF deterioration (HF requiring hospitalization or additional diuretics) during a 2‐year follow‐up period and categorized patients into HF (+) and HF (−) groups accordingly. The aforementioned parameters were compared between groups. Results Midterm HF deterioration occurred in 12 patients (13.9%). Compared to the HF (−) group, the HF (+) group presented a significantly higher ΔPCWP (Occ‐Pre) (9.5 ± 4.4 mmHg vs. 3.0 ± 3.3 mmHg; p 〈 0.001) and ΔPCWP (Post‐Pre) (4.0 ± 2.8 mmHg vs. 0.6 ± 1.8 mmHg; p = 0.004). Receiver operating characteristic curve analysis showed that the ΔPCWP (Occ‐Pre) cutoff value of 5.5 mmHg had excellent ability to predict HF deterioration (Area under the curve 0.886 [0.779–0.993], p 〈 0.001; sensitivity 0.917, specificity 0.824). Conclusions Increases in PCWP during BOT predict midterm HF deterioration after tASD‐closure. Close surveillance may be needed in patients with a ΔPCWP (Occ‐Pre) 〉 5 mmHg.
Type of Medium:
Online Resource
ISSN:
1522-1946
,
1522-726X
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2001555-0
Permalink
