In:
ADMET and DMPK, International Association of Physical Chemists (IAPC), Vol. 7, No. 3 ( 2019-08-04), p. 183-195
Abstract:
The purpose of the present study was to harmonize the protocol of equilibrium solubility measurements for poorly water-soluble drugs to lower inter-laboratory variance. The “mandatory” and “recommended” procedures for the shake-flask method were harmonized based on the knowledge and experiences of each company and information from the literature. The solubility of model drugs was measured by the harmonized protocol (HP) and the non-harmonized proprietary protocol of each company (nonHP). Albendazole, griseofulvin, dipyridamole, and glibenclamide were used as model drugs. When using the nonHP, the solubility values showed large inter-laboratory variance. In contrast, inter-laboratory variance was markedly reduced when using the HP.
Type of Medium:
Online Resource
ISSN:
1848-7718
Language:
Unknown
Publisher:
International Association of Physical Chemists (IAPC)
Publication Date:
2019
detail.hit.zdb_id:
3018242-6
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