In:
Clinical Endocrinology, Wiley, Vol. 80, No. 5 ( 2014-05), p. 751-756
Abstract:
Data on reference intervals of thyroid functions in S outheast A sia are limited. The aim of this study was to provide reference ranges of thyroid functions and thyroid autoantibodies in T hais. Design and Methods Serum samples from 2545 apparently healthy non‐pregnant subjects, aged ≥14 years, from the fourth T hai N ational H ealth E xamination S urvey were measured for TSH , FT 4, antithyroperoxidase ( TPO A b), antithyroglobulin ( T g A b) and antithyrotrophin receptor antibodies ( TRA b). A reference population was selected from the disease‐free population by excluding those who had thyroid autoantibodies and TSH 〉 20 mIU/l. Results For the total population, median TSH and FT 4 levels were 1·94 mIU/l and 1·35 ng/dl, respectively. TSH was higher and FT 4 was lower in females than in males. Based on N ational A cademy of C linical B iochemistry criteria, the reference intervals (2·5th–97·5th percentile) were: TSH , 0·34–5·11 mIU/l; FT 4, 0·98–1·79 ng/dl; TPO Ab, 5–84·88 IU/ml; T g A b, 10–118·2 IU/ml; and TRA b, 0·3–1·24 IU/l. With the new reference ranges, hypothyroidism was found in 4·16% of the total population (0·78% overt and 3·38% subclinical hypothyroidism) and hyperthyroidism was found in 3·18% (0·94% overt and 2·24% subclinical hyperthyroidism). Positive TPO A b, T g A b and TRA b were found in 8·96%, 12·26% and 5·93%, respectively. The upper normal limit of TSH tended to increase with age, particularly for those aged 80 years and older. Conclusions The reference interval for TSH needs to be derived from each specific population. Slightly elevated TSH concentrations in the elderly could be considered acceptable, with no need for thyroxine treatment.
Type of Medium:
Online Resource
ISSN:
0300-0664
,
1365-2265
DOI:
10.1111/cen.2014.80.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2004597-9
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