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  • The American Association of Immunologists  (4)
  • Oh, Joa Sub  (4)
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  • The American Association of Immunologists  (4)
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Subjects(RVK)
  • 1
    Online Resource
    Online Resource
    Anti-obesity effect of Sargassum muticum (Yendo) Fensholt in high fat diet-induced obese mice (P5092)
    The American Association of Immunologists ; 2013
    In:  The Journal of Immunology Vol. 190, No. 1_Supplement ( 2013-05-01), p. 180.29-180.29
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 190, No. 1_Supplement ( 2013-05-01), p. 180.29-180.29
    Abstract: In this study, we investigated the ethanol extract of Sargassum muticum (Yendo) Fensholt (ESMF) attenuate high-fat-diet-induced obesity in 57BL/6 mice. The mice were maintained on a normal diet (ND), high-fat-die (HFD) and Oral administration of ESMF with HFD for 6 weeks. ESMF administration with HFD significantly decreased the body weight gain, fat tissue content and serum total cholesterol and triglyceride levels in comparison with the HFD group. The food intakes among the groups did not show significant changes but ESMF administration groups observed significant reduction energy efficiency ratio (EER) values in comparison with the HFD group. ESMF administration with HFD induced a significant decrease in lipid droplet accumulation in the liver tissue. We demonstrated the ESMF elevated AMPK phosphoryation and activation of ACC phosphorylation in a dose-dependent manner. Our findings suggest that ESMF may be anti-obesity effect on HFD-induced mice through activating AMPK pathway.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.190.Supp.180.29
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 2013
    detail.hit.zdb_id: 1475085-5
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    2-linoleoylglycerol inhibits allergic response and expression of inflammatory cytokines in mast cells (55.19)
    The American Association of Immunologists ; 2011
    In:  The Journal of Immunology Vol. 186, No. 1_Supplement ( 2011-04-01), p. 55.19-55.19
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 186, No. 1_Supplement ( 2011-04-01), p. 55.19-55.19
    Abstract: Mast cell-mediated allergic disorder is associated with many diseases such as allergic asthma, atopic dermatitis and allergic rhinitis. In this study, we investigated the effect of the 2-linoleoylglycerol isolated from Adenophora triphylla on the Immunoglobulin E (IgE)-mediated allergic response and expression of inflammatory cytokines in mast cells. We observed that 2-linoleoylglycerol significantly inhibited β-hexosaminidase release in a dose-dependent manner in antigen-stimulated RBL-2H3 mast cells. 2-linoleoylglycerol also suppressed the expression of TNF-α, IL-4, IL-10 and COX-2 mRNA in mast cells. In addition, we showed that 2-linoleoylglycerol attenuated the activating phosphorylation of AKT, p38MAPK, JNK and ERK1/2. Our findings suggest that 2-linoleoylglycerol inhibits mast cell-derived allergic response and expression of inflammatory cytokines and that this effect is related by inhibition of AKT, p38MAPK, JNK and ERK1/2 phosphorylations.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.186.Supp.55.19
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 2011
    detail.hit.zdb_id: 1475085-5
    Location Call Number Limitation Availability
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Anti-Obesity Effect of Ethyl Acetate Extracts from Agrimonia pilosa Ledeb. in 3T3-L1 preadipocytes (62.3)
    The American Association of Immunologists ; 2012
    In:  The Journal of Immunology Vol. 188, No. 1_Supplement ( 2012-05-01), p. 62.3-62.3
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 188, No. 1_Supplement ( 2012-05-01), p. 62.3-62.3
    Abstract: To evaluate the anti-obesity effect of Agrimoniae pilosa L., this study investigated that ethyl acetate extract from A. pilosa L. (EAAP) suppresses lipid accumulation and inhibits expression of adipogenic marker genes, such as peroxisome proliferator activated receptor γ (PPARγ), CCAAT-enhancer-binding protein α (C/EBPα), glucose transporter 4 (GLUT4), and adiponectin in 3T3-L1 preadipocytes. We demonstrated that EAAP inhibited adipocyte differentiation and expression of PPARγ and C/EBPα mRNA levels in a dose-dependent manner. In addition, EAAP reduced the PPARγ transcriptional activity stimulated by rosiglitazone in HEK 293T cells and decreased the expression of GLUT4 and adiponectin in 3T3-L1 cells. These results suggest that EAAP inhibits preadipocyte differentiation and adipogenesis by blocking of PPARγ and C/EBPα gene expression in 3T3-L1 cells.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.188.Supp.62.3
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 2012
    detail.hit.zdb_id: 1475085-5
    Location Call Number Limitation Availability
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Inhibitory Effect of Sargassum muticum (Yendo) Fensholt on Adipogenesis in 3T3-L1 Cells (44.29)
    The American Association of Immunologists ; 2012
    In:  The Journal of Immunology Vol. 188, No. 1_Supplement ( 2012-05-01), p. 44.29-44.29
    Details
    In: The Journal of Immunology, The American Association of Immunologists, Vol. 188, No. 1_Supplement ( 2012-05-01), p. 44.29-44.29
    Abstract: In this study, we investigated the ethanol extract of Sargassum muticum (Yendo) Fensholt (ESMF) inhibits adipocyte differentiation and expression of adipogenic marker genes, such as PPARγ (peroxisome proliferator activated receptor γ), C/EBPα (CCAAT-enhancer-binding protein α), GLUT4 (glucose transporter 4), adiponectin, aP2 (adipocyte fatty acid-binding protein 2) and ADD1/SREBP1c (adipocyte determination and differentiation factor 1/sterol regulatory element binding protein 1c) in 3T3-L1 cells. We demonstrated that ESMF induced a significant decrease in lipid accumulation and expression of adipogenic marker genes in a dose-dependent manner. In addition, ESMF reduced the transcripitional activity of PPARγ induced by troglitazone, a potent diabetes agent; it also suppressed expression of PPARγ and C/EBPα protein levels. Our findings provide that ESMF inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression.
    Type of Medium: Online Resource
    ISSN: 0022-1767 , 1550-6606
    URL: Article
    DOI: 10.4049/jimmunol.188.Supp.44.29
    RVK:
    XA 54100
    RVK:
    XA 10000
    Language: English
    Publisher: The American Association of Immunologists
    Publication Date: 2012
    detail.hit.zdb_id: 1475085-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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