In:
FEBS Letters, Wiley, Vol. 495, No. 3 ( 2001-04-27), p. 142-147
Abstract:
Adhesion molecules such as vascular cell adhesion molecule‐1 (VCAM‐1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti‐atherogenic effect in low density lipoprotein receptor −/− mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM‐1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 μM), a major component of A. rugosa , inhibits the tumor necrotic factor‐α (TNF‐α)‐induced expression of VCAM‐1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 μM) reduced TNF‐α‐induced activation of nuclear factor‐κB in HUVECs.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(01)02379-1
Language:
English
Publisher:
Wiley
Publication Date:
2001
detail.hit.zdb_id:
1460391-3
SSG:
12
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