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  • 1
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    Ovid Technologies (Wolters Kluwer Health) ; 2017
    In:  Critical Care Medicine Vol. 45, No. 3 ( 2017-03), p. e328-e329
    Details
    In: Critical Care Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 45, No. 3 ( 2017-03), p. e328-e329
    Type of Medium: Online Resource
    ISSN: 0090-3493
    URL: Article
    DOI: 10.1097/CCM.0000000000002225
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2017
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  • 2
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    Comparison of image quality and spatial resolution between 18F, 68Ga, and 64Cu phantom measurements using a digital Biograph Vision PET/CT
    Springer Science and Business Media LLC ; 2022
    In:  EJNMMI Physics Vol. 9, No. 1 ( 2022-09-05)
    Details
    In: EJNMMI Physics, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2022-09-05)
    Abstract: PET nuclides can have a considerable influence on the spatial resolution and image quality of PET/CT scans, which can influence diagnostics in oncology, for example. The individual impact of the positron energy of 18 F, 68 Ga, and 64 Cu on spatial resolution and image quality was compared for PET/CT scans acquired using a clinical, digital scanner. Methods A Jaszczak phantom and a NEMA PET body phantom were filled with 18 F-FDG, 68 Ga-HCl, or 64 Cu-HCl, and PET/CT scans were performed on a Siemens Biograph Vision. Acquired images were analyzed regarding spatial resolution and image quality (recovery coefficients (RC), coefficient of variation within the background, contrast recovery coefficient (CRC), contrast–noise ratio (CNR), and relative count error in the lung insert). Data were compared between scans with different nuclides. Results We found that image quality was comparable between 18 F-FDG and 64 Cu-HCl PET/CT measurements featuring similar maximal endpoint energies of the positrons. In comparison, RC, CRC, and CNR were degraded in 68 Ga-HCl data despite similar count rates. In particular, the two smallest spheres of 10 mm and 13 mm diameter revealed lower RC, CRC, and CNR values. The spatial resolution was similar between 18 F-FDG and 64 Cu-HCl but up to 18% and 23% worse compared with PET/CT images of the NEMA PET body phantom filled with 68 Ga-HCl. Conclusions The positron energy of the PET nuclide influences the spatial resolution and image quality of a digital PET/CT scan. The image quality and spatial resolution of 68 Ga-HCl PET/CT images were worse than those of 18 F-FDG or 64 Cu-HCl despite similar count rates.
    Type of Medium: Online Resource
    ISSN: 2197-7364
    URL: Article
    DOI: 10.1186/s40658-022-00487-7
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2768912-8
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  • 3
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    Comparative Effects of Volutrauma and Atelectrauma on Lung Inflammation in Experimental Acute Respiratory Distress Syndrome
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Critical Care Medicine Vol. 44, No. 9 ( 2016-09), p. e854-e865
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    In: Critical Care Medicine, Ovid Technologies (Wolters Kluwer Health), Vol. 44, No. 9 ( 2016-09), p. e854-e865
    Abstract: Volutrauma and atelectrauma promote ventilator-induced lung injury, but their relative contribution to inflammation in ventilator-induced lung injury is not well established. The aim of this study was to determine the impact of volutrauma and atelectrauma on the distribution of lung inflammation in experimental acute respiratory distress syndrome. Design: Laboratory investigation. Setting: University-hospital research facility. Subjects: Ten pigs (five per group; 34.7–49.9 kg) Interventions: Animals were anesthetized and intubated, and saline lung lavage was performed. Lungs were separated with a double-lumen tube. Following lung recruitment and decremental positive end-expiratory pressure trial, animals were randomly assigned to 4 hours of ventilation of the left (ventilator-induced lung injury) lung with tidal volume of approximately 3 mL/kg and 1) high positive end-expiratory pressure set above the level where dynamic compliance increased more than 5% during positive end-expiratory pressure trial (volutrauma); or 2) low positive end-expiratory pressure to achieve driving pressure comparable with volutrauma (atelectrauma). The right (control) lung was kept on continuous positive airway pressure of 20 cm H 2 O, and C o 2 was partially removed extracorporeally. Measurements and Main Results: Regional lung aeration, specific [ 18 F]fluorodeoxyglucose uptake rate, and perfusion were assessed using computed and positron emission tomography. Volutrauma yielded higher [ 18 F]fluorodeoxyglucose uptake rate in the ventilated lung compared with atelectrauma (median [interquartile range] , 0.017 [0.014–0.025] vs 0.013 min –1 [0.010–0.014 min –1 ]; p 〈 0.01), mainly in central lung regions. Volutrauma yielded higher [ 18 F]fluorodeoxyglucose uptake rate in ventilator-induced lung injury versus control lung (0.017 [0.014–0.025] vs 0.011 min –1 [0.010–0.016 min –1 ]; p 〈 0.05), whereas atelectrauma did not. Volutrauma decreased blood fraction at similar perfusion and increased normally as well as hyperaerated lung compartments and tidal hyperaeration. Atelectrauma yielded higher poorly and nonaerated lung compartments, and tidal recruitment. Driving pressure increased in atelectrauma. Conclusions: In this model of acute respiratory distress syndrome, volutrauma promoted higher lung inflammation than atelectrauma at comparable low tidal volume and lower driving pressure, suggesting that static stress and strain are major determinants of ventilator-induced lung injury.
    Type of Medium: Online Resource
    ISSN: 0090-3493
    URL: Article
    DOI: 10.1097/CCM.0000000000001721
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
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  • 4
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    Induction and rejoining of DNA double-strand breaks in the lymphocytes of prostate cancer patients after radium-223 treatment as assessed by the γH2AX foci assay
    Georg Thieme Verlag KG ; 2019
    In:  Nuklearmedizin Vol. 58, No. 05 ( 2019-09), p. 387-394
    Details
    In: Nuklearmedizin, Georg Thieme Verlag KG, Vol. 58, No. 05 ( 2019-09), p. 387-394
    Abstract: Aim The aim of this study is to assess if the number of radiation-induced double strand breaks (DSB) in lymphocytes of prostate cancer patients is affected after repeated Ra-223 therapies. In addition, we investigated the repair of ex vivo induced DSB to investigate the repair proficiency in patient’s lymphocytes over the therapy course. Methods Before each of six therapy cycles, blood samples were obtained from seventeen patients. After separation of lymphocytes, the cells were subjected to immunofluorescence staining for detection of DSB-marking γH2AX foci. The number of foci per cell per patient sample was determined for each cycle (X1-X6, baseline foci per cell). Additionally, appropriate samples were exposed ex vivo to an X-ray dose of 1 Gy. The number of γH2AX foci per cell were analyzed after 0.5 h, 2 h and 24 h of recovery. Results Patient-specific linear regression of the baseline foci per cell over the therapy cycles revealed no significant slopes in the regression lines. Likewise, the mean baseline foci per cell of all patients for cycles X2-X6 was not significantly elevated in comparison to the pre-therapeutic value (X1). The differences between the percentages of residual DSB and cycles were not significant, both at 2 h and 24 h repair time. Consideration of the X6/X1 ratios of both the number of lymphocytes and the amount of residual damage at 24 h indicated a significant correlation. Conclusion Our findings indicate that the number of γH2AX foci per cell was not changed in dependence on the Ra-223 therapy cycles. The ability of patient’s lymphocytes to repair ex vivo induced DSB remained unaffected throughout the entire therapy course.
    Type of Medium: Online Resource
    ISSN: 0029-5566 , 2567-6407
    URL: Article
    DOI: 10.1055/a-0974-3767
    Language: English
    Publisher: Georg Thieme Verlag KG
    Publication Date: 2019
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