In:
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Wiley, Vol. 89B, No. 2 ( 2009-05), p. 293-299
Abstract:
Introduction: Formation of postoperative intra‐abdominal adhesions is a severe problem in surgery. Apart from standard surgical procedures, a variety of different substances is available to prevent adhesions, but no universal method has been developed so far. A membrane consisting of polyvinyl alcohol (PVA) and carboxymethylcellulose (CMC) has been demonstrated to be antiadhesive. Here, the in vitro testing and first in vivo results in a rabbit sidewall model are reported. Materials and Methods: A‐part® membrane contains a PVA/CMC mixture in a thickness of 40 μm. The composition, dissolution, tensile strength, and elasticity were examined to characterize the membrane in vitro . Experiments in vivo were carried out using a ‘rabbit sidewall model’ in which a standardized peritoneal trauma was covered with a 5 × 6 cm A‐part® membrane. Adhesion formation in A‐part®‐treated animals was compared with that in Adept® (15 mL/kg body weight) and untreated controls. Results: An 80/20 PVA/CMC mixture forms a stable, elastic, transparent membrane, which can easily be placed intraoperatively. The dissolution shows a half‐life of about 2 weeks [day 15: (45.1 ± 4.9)% SD], which affords good adhesion protection during the initial critical phase of adhesion formation. In wet conditions, the membrane follows abdominal movements without tearing (tensile strength 5.0 ± 4.2 N/cm SD; elasticity 29.5%). In a rabbit sidewall model, A‐part® membrane significantly reduced adhesion development by (83.1 ± 31.5)% SD compared with the control and the Adept group ( p 〈 0.001). Conclusion: The properties of the A‐part® membrane suggest that it may be useful as an antiadhesive in surgery. A‐part® is effective in invivo testing as determined in a rabbit sidewall model. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009
Type of Medium:
Online Resource
ISSN:
1552-4973
,
1552-4981
DOI:
10.1002/jbm.b.v89b:2
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2130917-6
SSG:
12
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