In:
Journal of Porphyrins and Phthalocyanines, World Scientific Pub Co Pte Ltd, Vol. 08, No. 11 ( 2004-11), p. 1289-1292
Abstract:
Photodynamic therapy (PDT) is one of the most effective treatments for cancer. We synthesized and characterized a series of 16 glycoconjugated porphyrins using a modification of the Lindsey method in the presence of Zn ( OAc ) 2 ·2 H 2 O as a template. The Zn 2+ ion template strategy improved the yield about 3-fold in the case of meta-substituted tetraphenylporphyrins, and free-base porphyrins were obtaind almost quantitatively by demetalation with 4 M HCl . The hydrophobicity parameter (Log P) of these porphyrins was evaluated by reversed phase high-performance liquid chromatography (RP-HPLC). The Log P values ranged from +4.8 to +7.8, so that most of the compounds are amphiphilic. The effect of the glycopyranosyl unit on the hydrophobicity of these compounds is discussed on the basis of the Log P value.
Type of Medium:
Online Resource
ISSN:
1088-4246
,
1099-1409
DOI:
10.1142/S1088424604000659
Language:
English
Publisher:
World Scientific Pub Co Pte Ltd
Publication Date:
2004
detail.hit.zdb_id:
1387701-X
detail.hit.zdb_id:
2001677-3
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