In:
European Journal of Immunology, Wiley, Vol. 49, No. 6 ( 2019-06), p. 853-872
Abstract:
BM has been put forward as a major reservoir for memory CD8 + T cells. In order to fulfill that function, BM should “store” memory CD8 + T cells, which in biological terms would require these “stored” memory cells to be in disequilibrium with the circulatory pool. This issue is a matter of ongoing debate. Here, we unequivocally demonstrate that murine and human BM harbors a population of tissue‐resident memory CD8 + T (T RM ) cells. These cells develop against various pathogens, independently of BM infection or local antigen recognition. BM CD8 + T RM cells share a transcriptional program with resident lymphoid cells in other tissues; they are polyfunctional cytokine producers and dependent on IL‐15, Blimp‐1, and Hobit. CD8 + T RM cells reside in the BM parenchyma, but are in close contact with the circulation. Moreover, this pool of resident T cells is not size‐restricted and expands upon peripheral antigenic re‐challenge. This works extends the role of the BM in the maintenance of CD8 + T cell memory to include the preservation of an expandable reservoir of functional, non‐recirculating memory CD8 + T cells, which develop in response to a large variety of peripheral antigens.
Type of Medium:
Online Resource
ISSN:
0014-2980
,
1521-4141
DOI:
10.1002/eji.201848003
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
1491907-2
Permalink