In:
BMC Cancer, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2013-12)
Abstract:
A subset of lung adenocarcinomas harboring an EML4-ALK fusion gene resulting in dominant oncogenic activity has emerged as a target for specific therapy. EML4-ALK fusion confers a characteristic histology and is detected more frequently in never or light smokers and younger patients. Methods To gain insights into etiology and carcinogenic mechanisms we conducted analyses to compare allelotypes of 35 ALK fusion-positive and 95 -negative tumours using single nucleotide polymorphism (SNP) arrays and especially designed software which enabled precise global genomic profiling. Results Overall aberration numbers (gains + losses) of chromosomal alterations were 8.42 and 9.56 in tumours with and without ALK fusion, respectively, the difference not being statistically significant, although patterns of gain and loss were distinct. Interestingly, among selected genomic regions, oncogene-related examples such as 1p34.3( MYCL1 ), 7q11.2( EGFR ), 7p21.1, 8q24.21( MYC ), 16p13.3, 17q12( ERBB2 ) and 17q25.1 showed significantly less gain. Also, changes in tumour suppressor gene-related regions, such as 9p21.3 ( CDKN2A ) 9p23-24.1 ( PTPRD ), 13q14.2 ( RB1 ), were significantly fewer in tumours with ALK fusion. Conclusion Global genomic comparison with SNP arrays showed tumours with ALK fusion to have fewer alterations in oncogenes and suppressor genes despite a similar overall aberration frequency, suggesting very strong oncogenic potency of ALK activation by gene fusion.
Type of Medium:
Online Resource
ISSN:
1471-2407
DOI:
10.1186/1471-2407-13-8
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2013
detail.hit.zdb_id:
2041352-X
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